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Q3A9L1

- PANC_CARHZ

UniProt

Q3A9L1 - PANC_CARHZ

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Protein
Pantothenate synthetase
Gene
panC, CHY_2376
Organism
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donor By similarity
Binding sitei61 – 611Beta-alanine By similarity
Binding sitei61 – 611Pantoate By similarity
Binding sitei154 – 1541Pantoate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATP By similarity
Nucleotide bindingi148 – 1514ATP By similarity
Nucleotide bindingi185 – 1884ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-2375-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:CHY_2376
OrganismiCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
ProteomesiUP000002706: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Pantothenate synthetaseUniRule annotation
PRO_0000305422Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi246194.CHY_2376.

Structurei

3D structure databases

ProteinModelPortaliQ3A9L1.
SMRiQ3A9L1. Positions 1-280.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175517.
KOiK01918.
OMAiHAGHMEL.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3A9L1-1 [UniParc]FASTAAdd to Basket

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MRFFTEIKPL KTYVAEQKRE GKIIGFVPTM GYLHDGHLSL VRKAKLQADV    50
VIVSIFVNPL QFGPNEDFAK YPRDLERDLA LLQEEGVDCV FAPSAEEMYK 100
EGFSTFVEVN GEITEVMCGK SRPGHFKGVA TVVTKLFNIV TPDLAFFGQK 150
DAQQLFIIEK LVRDLNLNVE IVSVPTRREE DGLAMSSRNT YLNPEERKAA 200
TILYRALKRG EELVLAGERN PERLKKLIEE FIKTEPLARI DYVEVRSVPD 250
LKAMDVIKGK FIIALAVYIG STRLIDNFIL EVD 283
Length:283
Mass (Da):32,102
Last modified:November 22, 2005 - v1
Checksum:iAB9D2CF61C9E16BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000141 Genomic DNA. Translation: ABB14551.1.
RefSeqiWP_011345246.1. NC_007503.1.
YP_361173.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB14551; ABB14551; CHY_2376.
GeneIDi3726723.
KEGGichy:CHY_2376.
PATRICi21277819. VBICarHyd26463_2255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000141 Genomic DNA. Translation: ABB14551.1 .
RefSeqi WP_011345246.1. NC_007503.1.
YP_361173.1. NC_007503.1.

3D structure databases

ProteinModelPortali Q3A9L1.
SMRi Q3A9L1. Positions 1-280.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246194.CHY_2376.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB14551 ; ABB14551 ; CHY_2376 .
GeneIDi 3726723.
KEGGi chy:CHY_2376.
PATRICi 21277819. VBICarHyd26463_2255.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175517.
KOi K01918.
OMAi HAGHMEL.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci CHYD246194:GJCN-2375-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-2901 / DSM 6008.

Entry informationi

Entry nameiPANC_CARHZ
AccessioniPrimary (citable) accession number: Q3A9L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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