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Q3A9K2 (FTHS_CARHZ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:CHY_2385
OrganismCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]
Taxonomic identifier246194 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300517

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3A9K2 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: FC3BE24A4453725D

FASTA55660,090
        10         20         30         40         50         60 
MKSDIEIAQE AKLEPIVKIA EKLGLTEDDI ELYGKYKAKI AAHVWDRIKD RPDGKLILVT 

        70         80         90        100        110        120 
AINPTPAGEG KTTTTVGLGD ALSRLGKKTV IALREPSLGP SFGVKGGAAG GGYAQVVPME 

       130        140        150        160        170        180 
DINLHFTGDL HAITTAHNLL AAMIDNHIHQ GNELGIDPRR VVWRRVVDLN DRALRKVVIG 

       190        200        210        220        230        240 
LGGPAQGVPR ETGFDITVAS EIMAILCLAS DLMDLKERFN RILIGYTYDQ KPVYARDLKA 

       250        260        270        280        290        300 
AGAMTVLMKD AIKPNLVQTL EHTPAFVHGG PFANIAHGTN SILADKIALK LADYLVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF FNVVCRFAGF KPSAVVIVAT VRALKYNGGV PRAELNKENL EALEKGFANL 

       370        380        390        400        410        420 
EKHIENIGKF GLPAVVAINR FPTDTDAELN KLRELIEATG AEFALSEVWA KGGEGGIELA 

       430        440        450        460        470        480 
QKVLKVIEEK PANFRYLYDL EMPIKQKIET IAREIYGADG VVFTADAEKT LAKFEEMGFG 

       490        500        510        520        530        540 
NMPVIMAKTQ YSLSDDPNKL GRPTGFNITV RELRASVGAG FIVAITGDIM TMPGLPKRPA 

       550 
AEVIDIDADG KITGLF 

« Hide

References

[1]"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901."
Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.
PLoS Genet. 1:563-574(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Z-2901 / DSM 6008.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000141 Genomic DNA. Translation: ABB16038.1.
RefSeqYP_361182.1. NC_007503.1.

3D structure databases

ProteinModelPortalQ3A9K2.
SMRQ3A9K2. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246194.CHY_2385.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB16038; ABB16038; CHY_2385.
GeneID3728149.
KEGGchy:CHY_2385.
PATRIC21277833. VBICarHyd26463_2262.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycCHYD246194:GJCN-2384-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_CARHZ
AccessionPrimary (citable) accession number: Q3A9K2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 22, 2005
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways