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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCHYD246194:G1G5B-2221-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:CHY_2385
OrganismiCarboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
Proteomesi
  • UP000002706 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003005171 – 556Formate--tetrahydrofolate ligaseAdd BLAST556

Proteomic databases

PRIDEiQ3A9K2

Interactioni

Protein-protein interaction databases

STRINGi246194.CHY_2385

Structurei

3D structure databases

ProteinModelPortaliQ3A9K2
SMRiQ3A9K2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3A9K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDIEIAQE AKLEPIVKIA EKLGLTEDDI ELYGKYKAKI AAHVWDRIKD
60 70 80 90 100
RPDGKLILVT AINPTPAGEG KTTTTVGLGD ALSRLGKKTV IALREPSLGP
110 120 130 140 150
SFGVKGGAAG GGYAQVVPME DINLHFTGDL HAITTAHNLL AAMIDNHIHQ
160 170 180 190 200
GNELGIDPRR VVWRRVVDLN DRALRKVVIG LGGPAQGVPR ETGFDITVAS
210 220 230 240 250
EIMAILCLAS DLMDLKERFN RILIGYTYDQ KPVYARDLKA AGAMTVLMKD
260 270 280 290 300
AIKPNLVQTL EHTPAFVHGG PFANIAHGTN SILADKIALK LADYLVTEAG
310 320 330 340 350
FGADLGAEKF FNVVCRFAGF KPSAVVIVAT VRALKYNGGV PRAELNKENL
360 370 380 390 400
EALEKGFANL EKHIENIGKF GLPAVVAINR FPTDTDAELN KLRELIEATG
410 420 430 440 450
AEFALSEVWA KGGEGGIELA QKVLKVIEEK PANFRYLYDL EMPIKQKIET
460 470 480 490 500
IAREIYGADG VVFTADAEKT LAKFEEMGFG NMPVIMAKTQ YSLSDDPNKL
510 520 530 540 550
GRPTGFNITV RELRASVGAG FIVAITGDIM TMPGLPKRPA AEVIDIDADG

KITGLF
Length:556
Mass (Da):60,090
Last modified:November 22, 2005 - v1
Checksum:iFC3BE24A4453725D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA Translation: ABB16038.1
RefSeqiWP_011345255.1, NC_007503.1

Genome annotation databases

EnsemblBacteriaiABB16038; ABB16038; CHY_2385
KEGGichy:CHY_2385

Similar proteinsi

Entry informationi

Entry nameiFTHS_CARHZ
AccessioniPrimary (citable) accession number: Q3A9K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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