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Q3A9K2

- FTHS_CARHZ

UniProt

Q3A9K2 - FTHS_CARHZ

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCHYD246194:GJCN-2384-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:CHY_2385
    OrganismiCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
    Taxonomic identifieri246194 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
    ProteomesiUP000002706: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300517Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246194.CHY_2385.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3A9K2.
    SMRiQ3A9K2. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3A9K2-1 [UniParc]FASTAAdd to Basket

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    MKSDIEIAQE AKLEPIVKIA EKLGLTEDDI ELYGKYKAKI AAHVWDRIKD    50
    RPDGKLILVT AINPTPAGEG KTTTTVGLGD ALSRLGKKTV IALREPSLGP 100
    SFGVKGGAAG GGYAQVVPME DINLHFTGDL HAITTAHNLL AAMIDNHIHQ 150
    GNELGIDPRR VVWRRVVDLN DRALRKVVIG LGGPAQGVPR ETGFDITVAS 200
    EIMAILCLAS DLMDLKERFN RILIGYTYDQ KPVYARDLKA AGAMTVLMKD 250
    AIKPNLVQTL EHTPAFVHGG PFANIAHGTN SILADKIALK LADYLVTEAG 300
    FGADLGAEKF FNVVCRFAGF KPSAVVIVAT VRALKYNGGV PRAELNKENL 350
    EALEKGFANL EKHIENIGKF GLPAVVAINR FPTDTDAELN KLRELIEATG 400
    AEFALSEVWA KGGEGGIELA QKVLKVIEEK PANFRYLYDL EMPIKQKIET 450
    IAREIYGADG VVFTADAEKT LAKFEEMGFG NMPVIMAKTQ YSLSDDPNKL 500
    GRPTGFNITV RELRASVGAG FIVAITGDIM TMPGLPKRPA AEVIDIDADG 550
    KITGLF 556
    Length:556
    Mass (Da):60,090
    Last modified:November 22, 2005 - v1
    Checksum:iFC3BE24A4453725D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000141 Genomic DNA. Translation: ABB16038.1.
    RefSeqiWP_011345255.1. NC_007503.1.
    YP_361182.1. NC_007503.1.

    Genome annotation databases

    EnsemblBacteriaiABB16038; ABB16038; CHY_2385.
    GeneIDi3728149.
    KEGGichy:CHY_2385.
    PATRICi21277833. VBICarHyd26463_2262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000141 Genomic DNA. Translation: ABB16038.1 .
    RefSeqi WP_011345255.1. NC_007503.1.
    YP_361182.1. NC_007503.1.

    3D structure databases

    ProteinModelPortali Q3A9K2.
    SMRi Q3A9K2. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246194.CHY_2385.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB16038 ; ABB16038 ; CHY_2385 .
    GeneIDi 3728149.
    KEGGi chy:CHY_2385.
    PATRICi 21277833. VBICarHyd26463_2262.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CHYD246194:GJCN-2384-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z-2901 / DSM 6008.

    Entry informationi

    Entry nameiFTHS_CARHZ
    AccessioniPrimary (citable) accession number: Q3A9K2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3