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Protein

Catalase-peroxidase

Gene

katG

Organism
Pelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei96Transition state stabilizerUniRule annotation1
Active sitei100Proton acceptorUniRule annotation1
Metal bindingi268Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2668. PcaCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Pcar_1175
OrganismiPelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
Taxonomic identifieri338963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesDesulfuromonadaceaePelobacter
Proteomesi
  • UP000002534 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548551 – 739Catalase-peroxidaseAdd BLAST739

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki99 ↔ 227Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-253)UniRule annotation
Cross-linki227 ↔ 253Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-99)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ3A5D3.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi338963.Pcar_1175.

Structurei

3D structure databases

ProteinModelPortaliQ3A5D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTRWSNNF.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3A5D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDSKCPVT GKTAKTAIPM TGRGTTNQDW WPNQLKLNIL HQHSSKSNPM
60 70 80 90 100
GGDFNYAEEF KKLDLAAVKQ DLYAMMTDSR EWWPADWGHY GGLLIRMAWH
110 120 130 140 150
SAGTYRMGDG RGGAGSGSQR LAPLNSWPDN VNLDKARRLL WPIKQKYGRK
160 170 180 190 200
ISWADLMVLA GNCALESMGF KTFGFAGGRE DAWEPEQDIY WGAEEEWLAT
210 220 230 240 250
SDKPKSRYSG DRDLENPLAA VQMGLIYVNP EGPDGNPDPV ASGRDVRETF
260 270 280 290 300
ARMAMNDEET VALVAGGHTF GKCHGAGPAT HVGPEPEAAP IEEQGLGWKS
310 320 330 340 350
SFGSGKGGDT ISSGIEGAWK PNPTKWDMGY LKVLFKYEWE KVKSPAGAWQ
360 370 380 390 400
WLAKDVDEED MIVGAHDPSK KFRPMMTTAD LSLRFDPIYE PIARRYLENP
410 420 430 440 450
EEFADAFARA WFKLTHRDMG PRSRYLGSEV PAEELIWQDP VPAVDHELID
460 470 480 490 500
AADIADLKVK ILASGLSIPQ LVSTAWASAS TFRGSDKRGG ANGARIRLAP
510 520 530 540 550
QKDWEVNQPA QLKTVLQTLE GIQQAFNGAQ AGGKKVSLAD LIVLGGCAAV
560 570 580 590 600
EQAAGNAGHD VTVPFTPGRT DATSEQTDVA SFSVLEPVAD GFRNYQKAKF
610 620 630 640 650
AVRAEELLVD RAQLLTLTAP EMTVLVGGMR VLNTNHGGTP HGVFTDRPET
660 670 680 690 700
LTNDFFVNLL DMGTTWQPTA EDADIFEGCD RATGELKWTG TRIDLVFGSN
710 720 730
SQLRAIAEVY GCADSGEKFV NDFVAVWSKI MNLDRFDLA
Length:739
Mass (Da):81,032
Last modified:November 22, 2005 - v1
Checksum:i23581357C49713CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000142 Genomic DNA. Translation: ABA88424.1.
RefSeqiWP_011340898.1. NC_007498.2.

Genome annotation databases

EnsemblBacteriaiABA88424; ABA88424; Pcar_1175.
KEGGipca:Pcar_1175.
PATRICi22888450. VBIPelCar86875_1298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000142 Genomic DNA. Translation: ABA88424.1.
RefSeqiWP_011340898.1. NC_007498.2.

3D structure databases

ProteinModelPortaliQ3A5D3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi338963.Pcar_1175.

Protein family/group databases

PeroxiBasei2668. PcaCP01.

Proteomic databases

PRIDEiQ3A5D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA88424; ABA88424; Pcar_1175.
KEGGipca:Pcar_1175.
PATRICi22888450. VBIPelCar86875_1298.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTRWSNNF.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_PELCD
AccessioniPrimary (citable) accession number: Q3A5D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.