Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3A4P8

- SYL_PELCD

UniProt

Q3A4P8 - SYL_PELCD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei615 – 6151ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPCAR338963:GKDU-1573-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Pcar_1413
    OrganismiPelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
    Taxonomic identifieri338963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesPelobacteraceaePelobacter
    ProteomesiUP000002534: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 851851Leucine--tRNA ligasePRO_1000009387Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi338963.Pcar_1413.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3A4P8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi612 – 6165"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3A4P8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEERYDAGGI EGKWQKRWEQ DRTFKAKEKD AREKYYLLEM FPYPSGRIHM    50
    GHVRNYSIGD VVARFKRLQG YNVLHPMGWD AFGMPAENAA IQHKTHPGKW 100
    TYENIDNMRA QLKKMGFSYD WDREVATCHP EYYRWEQLIF LKMLEKGLAY 150
    KKSSFVNWCS ECQTVLANEQ VENDACWRCG TVVEQKELEQ WFFKITDYAQ 200
    ELLDDTSKLS GWPEPVLTMQ RNWIGRSTGC EIDFPVADSD LKIKVFTTRQ 250
    DTLYGATFMS LAAEHPLAME LVSAECKAEV EAFIARVRTQ DKAKRTSDDF 300
    VKEGVFTGSY GINPVNGRRI PIYLANFVLM DYGTGAVMAV PTHDQRDFDF 350
    ARKYDIPMIV VIQPEDQTLD PATMTEAWTA PGVLVNSAPF DGLDNESAKE 400
    KIAAHLEEQG VGRKTVNYRL RDWGVSRQRY WGTPIPIIYC PACGIVPVPE 450
    EDLPVLLPMD VEISGEGGSP LARHQEFLKV TCPTCGGDAR RETDTFDTFV 500
    ESSWYFARYT CPRFEQGPVD RATVDHWLPV DQYIGGIEHA VMHLLYARFF 550
    TKVMRDLGMM AHDEPFKNLL TQGMVCMETA SCPEHGWLFP EQVVEGKCVL 600
    CGATAQTGRN EKMSKSKKNV VDPDKLILSY GADTARLFSL FAAPPEKDLE 650
    WNEQGVEGCY RFLHRVWRAV YDNLEMISGV AVPASVDGAA RNLRRQVHAT 700
    IKKVTGDIDG RFHFNTAIAS VMELVNAIYG FEAKAQYPGV MREALEATVR 750
    LLAPFVPHVC EELWACLGHE GGLEAAGWPA WDEEALVEDE KTIVVQVNGK 800
    VRGKLTIAAD ADNDTVQQAA LKADNVVRFL EGKTVRKVVV VPGRLVNIVV 850
    S 851
    Length:851
    Mass (Da):96,220
    Last modified:November 22, 2005 - v1
    Checksum:i4066676129891262
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000142 Genomic DNA. Translation: ABA88659.1.
    RefSeqiWP_011341142.1. NC_007498.2.
    YP_006717139.1. NC_007498.2.

    Genome annotation databases

    EnsemblBacteriaiABA88659; ABA88659; Pcar_1413.
    GeneIDi3723839.
    KEGGipca:Pcar_1413.
    PATRICi22888964. VBIPelCar86875_1550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000142 Genomic DNA. Translation: ABA88659.1 .
    RefSeqi WP_011341142.1. NC_007498.2.
    YP_006717139.1. NC_007498.2.

    3D structure databases

    ProteinModelPortali Q3A4P8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338963.Pcar_1413.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA88659 ; ABA88659 ; Pcar_1413 .
    GeneIDi 3723839.
    KEGGi pca:Pcar_1413.
    PATRICi 22888964. VBIPelCar86875_1550.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PCAR338963:GKDU-1573-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Pelobacter carbinolicus DSM 2380."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chertkov O., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2380 / Gra Bd 1.

    Entry informationi

    Entry nameiSYL_PELCD
    AccessioniPrimary (citable) accession number: Q3A4P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3