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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei615ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pcar_1413
OrganismiPelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
Taxonomic identifieri338963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesDesulfuromonadaceaePelobacter
Proteomesi
  • UP000002534 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093871 – 851Leucine--tRNA ligaseAdd BLAST851

Interactioni

Protein-protein interaction databases

STRINGi338963.Pcar_1413.

Structurei

3D structure databases

ProteinModelPortaliQ3A4P8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi612 – 616"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T. Bacteria.
COG0495. LUCA.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHRFIKRL.
OrthoDBiPOG091H01JZ.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 5 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3A4P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERYDAGGI EGKWQKRWEQ DRTFKAKEKD AREKYYLLEM FPYPSGRIHM
60 70 80 90 100
GHVRNYSIGD VVARFKRLQG YNVLHPMGWD AFGMPAENAA IQHKTHPGKW
110 120 130 140 150
TYENIDNMRA QLKKMGFSYD WDREVATCHP EYYRWEQLIF LKMLEKGLAY
160 170 180 190 200
KKSSFVNWCS ECQTVLANEQ VENDACWRCG TVVEQKELEQ WFFKITDYAQ
210 220 230 240 250
ELLDDTSKLS GWPEPVLTMQ RNWIGRSTGC EIDFPVADSD LKIKVFTTRQ
260 270 280 290 300
DTLYGATFMS LAAEHPLAME LVSAECKAEV EAFIARVRTQ DKAKRTSDDF
310 320 330 340 350
VKEGVFTGSY GINPVNGRRI PIYLANFVLM DYGTGAVMAV PTHDQRDFDF
360 370 380 390 400
ARKYDIPMIV VIQPEDQTLD PATMTEAWTA PGVLVNSAPF DGLDNESAKE
410 420 430 440 450
KIAAHLEEQG VGRKTVNYRL RDWGVSRQRY WGTPIPIIYC PACGIVPVPE
460 470 480 490 500
EDLPVLLPMD VEISGEGGSP LARHQEFLKV TCPTCGGDAR RETDTFDTFV
510 520 530 540 550
ESSWYFARYT CPRFEQGPVD RATVDHWLPV DQYIGGIEHA VMHLLYARFF
560 570 580 590 600
TKVMRDLGMM AHDEPFKNLL TQGMVCMETA SCPEHGWLFP EQVVEGKCVL
610 620 630 640 650
CGATAQTGRN EKMSKSKKNV VDPDKLILSY GADTARLFSL FAAPPEKDLE
660 670 680 690 700
WNEQGVEGCY RFLHRVWRAV YDNLEMISGV AVPASVDGAA RNLRRQVHAT
710 720 730 740 750
IKKVTGDIDG RFHFNTAIAS VMELVNAIYG FEAKAQYPGV MREALEATVR
760 770 780 790 800
LLAPFVPHVC EELWACLGHE GGLEAAGWPA WDEEALVEDE KTIVVQVNGK
810 820 830 840 850
VRGKLTIAAD ADNDTVQQAA LKADNVVRFL EGKTVRKVVV VPGRLVNIVV

S
Length:851
Mass (Da):96,220
Last modified:November 22, 2005 - v1
Checksum:i4066676129891262
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000142 Genomic DNA. Translation: ABA88659.1.
RefSeqiWP_011341142.1. NC_007498.2.

Genome annotation databases

EnsemblBacteriaiABA88659; ABA88659; Pcar_1413.
KEGGipca:Pcar_1413.
PATRICi22888964. VBIPelCar86875_1550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000142 Genomic DNA. Translation: ABA88659.1.
RefSeqiWP_011341142.1. NC_007498.2.

3D structure databases

ProteinModelPortaliQ3A4P8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi338963.Pcar_1413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA88659; ABA88659; Pcar_1413.
KEGGipca:Pcar_1413.
PATRICi22888964. VBIPelCar86875_1550.

Phylogenomic databases

eggNOGiENOG4105C8T. Bacteria.
COG0495. LUCA.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHRFIKRL.
OrthoDBiPOG091H01JZ.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 5 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYL_PELCD
AccessioniPrimary (citable) accession number: Q3A4P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.