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Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Pelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei61UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPCAR338963:G1G5C-1501-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferaseUniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferaseUniRule annotation
Protein L-isoaspartyl methyltransferaseUniRule annotation
Protein-beta-aspartate methyltransferaseUniRule annotation
Short name:
PIMTUniRule annotation
Gene namesi
Name:pcmUniRule annotation
Ordered Locus Names:Pcar_1427
OrganismiPelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
Taxonomic identifieri338963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesDesulfuromonadaceaePelobacter
Proteomesi
  • UP000002534 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003518951 – 217Protein-L-isoaspartate O-methyltransferaseAdd BLAST217

Proteomic databases

PRIDEiQ3A4N4

Interactioni

Protein-protein interaction databases

STRINGi338963.Pcar_1427

Structurei

3D structure databases

ProteinModelPortaliQ3A4N4
SMRiQ3A4N4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E26 Bacteria
COG2518 LUCA
HOGENOMiHOG000257189
KOiK00573
OMAiNQAYEDT
OrthoDBiPOG091H06AY

Family and domain databases

HAMAPiMF_00090 PIMT, 1 hit
InterProiView protein in InterPro
IPR000682 PCMT
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11579 PTHR11579, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00080 pimt, 1 hit

Sequencei

Sequence statusi: Complete.

Q3A4N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYSIARRLM VEQQVIRRGV SDPLVVDAMM RVPRHLFVEE ALWSQAYSDF
60 70 80 90 100
PLPIGEKQTI SQPFMVAFMT ESLCLHGGEK VLEIGTGSGY QAAVLSQIVS
110 120 130 140 150
RVYTVERLPG LARRARRILD SVGCRNVNIK LTDGTFGWEE ESPFDGIVVT
160 170 180 190 200
AGSPQIPHHY LEQLAVGGRL VIPVGNRGSQ VLKRVVRTGV EKFSEEDLLD
210
CRFVPLVGKY GWHEEGD
Length:217
Mass (Da):24,227
Last modified:November 22, 2005 - v1
Checksum:iEEE8B377A7BB9DC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000142 Genomic DNA Translation: ABA88673.1
RefSeqiWP_011341156.1, NC_007498.2

Genome annotation databases

EnsemblBacteriaiABA88673; ABA88673; Pcar_1427
KEGGipca:Pcar_1427

Similar proteinsi

Entry informationi

Entry nameiPIMT_PELCD
AccessioniPrimary (citable) accession number: Q3A4N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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