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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Pelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Binding sitei198SubstrateUniRule annotation1
Binding sitei228SubstrateUniRule annotation1
Binding sitei232SubstrateUniRule annotation1
Binding sitei233NADUniRule annotation1
Binding sitei285NADUniRule annotation1
Binding sitei320NADUniRule annotation1
Binding sitei389NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 201NADUniRule annotation3
Nucleotide bindingi262 – 267NADUniRule annotation6
Nucleotide bindingi341 – 343NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:Pcar_1924
OrganismiPelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
Taxonomic identifieri338963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesDesulfuromonadaceaePelobacter
Proteomesi
  • UP000002534 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000247421 – 475AdenosylhomocysteinaseAdd BLAST475

Proteomic databases

PRIDEiQ3A392.

Interactioni

Protein-protein interaction databases

STRINGi338963.Pcar_1924.

Structurei

3D structure databases

ProteinModelPortaliQ3A392.
SMRiQ3A392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3A392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSESISENY VVKDMGLAEW GRREIRMAEA EMPGLMAIRE EYRGTKPLAG
60 70 80 90 100
ARITGSLHMT IQTAVLIETL AELGADLRWA SCNIYSTQDH AAAAIAATGV
110 120 130 140 150
PVFAYKGETL EEYWEYTFKA LAYEEGPQLI VDDGGDATLL IHRGVERERA
160 170 180 190 200
YARTGKVPEI SHDNKELSIV DALLNRQLLV DAEYWQRMAT GLLGVSEETT
210 220 230 240 250
TGVHRLYHMA RNGELLFPAF NVNDSVTKSK FDNLYGCRES LIDGIKRATD
260 270 280 290 300
VMIAGKKCVV LGYGDVGKGC AQAFKGMGAL VSVTEVDPIC ALQAAMEGFA
310 320 330 340 350
VVDMDEACQW GDIFVTTTGN VDVITRSHMD VMKNEAIVCN IGHFDSEIQV
360 370 380 390 400
DALYDDPSLT VHEVKPQVDQ IEWPDGKRIT VLAKGRLVNL GCATGHPSFV
410 420 430 440 450
MSNSFTNQVL AQIELWQNSD RYENKVYVLP KQLDEKVARL HLANLGVKLT
460 470
RMTEKQADYL GVPVDGPYKP EHYRY
Length:475
Mass (Da):52,642
Last modified:November 22, 2005 - v1
Checksum:i45EE21F2FB69473F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000142 Genomic DNA. Translation: ABA89165.1.
RefSeqiWP_011341670.1. NC_007498.2.

Genome annotation databases

EnsemblBacteriaiABA89165; ABA89165; Pcar_1924.
KEGGipca:Pcar_1924.

Similar proteinsi

Entry informationi

Entry nameiSAHH_PELCD
AccessioniPrimary (citable) accession number: Q3A392
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: October 25, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families