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Q3A2G9 (DDL_PELCD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Pcar_2199
OrganismPelobacter carbinolicus (strain DSM 2380 / Gra Bd 1) [Complete proteome] [HAMAP]
Taxonomic identifier338963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesPelobacteraceaePelobacter

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341146

Regions

Domain107 – 299193ATP-grasp
Nucleotide binding134 – 18653ATP By similarity

Sites

Metal binding2541Magnesium or manganese 1 By similarity
Metal binding2661Magnesium or manganese 1 By similarity
Metal binding2661Magnesium or manganese 2 By similarity
Metal binding2681Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3A2G9 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 4817BB44EEFD7AAF

FASTA30532,716
        10         20         30         40         50         60 
MQRQELQQKK IAVLMGGLSA EREVSLRTGK AISQALTRCG YEVTDIDAGR DLAQQLEKTG 

        70         80         90        100        110        120 
VEVAFIALHG RFGEDGTVQG LLELADIPYT GSGVLASSLA MDKVATKKML CYHGIATPGF 

       130        140        150        160        170        180 
AVMRRGQKIC GTLPDYPLVV KPAREGSTIG ISIVHDEQEL AAGLEEAFRH DDLVLVEQFI 

       190        200        210        220        230        240 
AGAEVTVGVL DGQPLPIIQV VPKGGFYDYQ SKYTPGQTEY LLPAPLPETL YGALQDSAVR 

       250        260        270        280        290        300 
VFEAIGCCGA ARVDFMVTDT GFYCLEVNTI PGMTETSLLP KAANAVGMSF DELVERILAG 


ASLRK 

« Hide

References

[1]"Complete sequence of Pelobacter carbinolicus DSM 2380."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chertkov O., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 2380 / Gra Bd 1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000142 Genomic DNA. Translation: ABA89438.1.
RefSeqYP_006717951.1. NC_007498.2.

3D structure databases

ProteinModelPortalQ3A2G9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING338963.Pcar_2199.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA89438; ABA89438; Pcar_2199.
GeneID3724891.
KEGGpca:Pcar_2199.
PATRIC22890664. VBIPelCar86875_2382.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycPCAR338963:GKDU-2421-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_PELCD
AccessionPrimary (citable) accession number: Q3A2G9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 22, 2005
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways