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Q3A2D6

- PUR9_PELCD

UniProt

Q3A2D6 - PUR9_PELCD

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciPCAR338963:GKDU-2454-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Pcar_2232
    OrganismiPelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
    Taxonomic identifieri338963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesPelobacteraceaePelobacter
    ProteomesiUP000002534: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Bifunctional purine biosynthesis protein PurHPRO_1000057902Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi338963.Pcar_2232.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3A2D6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3A2D6-1 [UniParc]FASTAAdd to Basket

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    MAVIKRALIS VSDKTGIVEF ARELAGYGVE ILSTGGTAAL LRQEGLAVKD    50
    VSEYTGFPEM LDGRVKTLHP KVHGGLLGMR ENPAHVAKMK EHGIEPIDMV 100
    VVNLYPFEAT VAKPDCTLED AIENIDIGGP TMLRSAAKNN RDVTVVVDHV 150
    DYDQVLAEMK GSGGAVSRGT NFKLAVKVYQ HTAAYDGAIS NWLGQRMGDE 200
    LADFSDTLTV QFKKVQDMRY GENPHQKAAF YVERDVQEAS ISTSRQLQGK 250
    ELSYNNIADT DAALECVKQF NEGPACVIVK HANPCGVALG SNLLEAYNRA 300
    FSTDSESAFG GIIAFNRELD GTTAQAIVER QFVEVIIAPA VSAEAIDVVA 350
    TKKNVRLLEC GYWPQEPGAR YDFKRVNGGL LVQDADLLLS GDIKPVTKRV 400
    PTEEEMRDLL FTWRVAKFVK SNAIVYGKDG MTIGVGAGQM SRVNSARIAG 450
    IKAELAGLEV PGSVMASDAF FPFRDGLDNA AKAGIKAVIQ PGGSIRDEEV 500
    IAAADEHGIA MVFTGMRHFR H 521
    Length:521
    Mass (Da):56,353
    Last modified:November 22, 2005 - v1
    Checksum:i037CA41FFBCB8BB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000142 Genomic DNA. Translation: ABA89471.1.
    RefSeqiYP_006717984.1. NC_007498.2.

    Genome annotation databases

    EnsemblBacteriaiABA89471; ABA89471; Pcar_2232.
    GeneIDi3724905.
    KEGGipca:Pcar_2232.
    PATRICi22890730. VBIPelCar86875_2415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000142 Genomic DNA. Translation: ABA89471.1 .
    RefSeqi YP_006717984.1. NC_007498.2.

    3D structure databases

    ProteinModelPortali Q3A2D6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338963.Pcar_2232.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA89471 ; ABA89471 ; Pcar_2232 .
    GeneIDi 3724905.
    KEGGi pca:Pcar_2232.
    PATRICi 22890730. VBIPelCar86875_2415.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci PCAR338963:GKDU-2454-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Pelobacter carbinolicus DSM 2380."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chertkov O., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2380 / Gra Bd 1.

    Entry informationi

    Entry nameiPUR9_PELCD
    AccessioniPrimary (citable) accession number: Q3A2D6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3