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Q39ZQ5 (HEMH_GEOMG) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Gmet_0019
OrganismGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210) [Complete proteome] [HAMAP]
Taxonomic identifier269799 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Ferrochelatase HAMAP MF_00323
PRO_1000019305

Sites

Metal binding1921Iron By similarity
Metal binding2711Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q39ZQ5 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: C8EE9C2A42F7061D

FASTA31735,817
        10         20         30         40         50         60 
MSEKTAVLLL QMGGPDSLDA VEPFLVNLFS DRDIIRIGPA FLQPFIARLI AKKRATPVER 

        70         80         90        100        110        120 
KYEEIGGKSP IRELTEAQAK ALEEVLGDGY CCFTAMRYWK PTTVEALAAI RREGITRIIA 

       130        140        150        160        170        180 
LSLYPHYSRA TTGSSVNELK RVLAQSGATF DVTYVDRFFD HPRYIEALAE KIKEGLDDFH 

       190        200        210        220        230        240 
PLAEVQILFS AHSLPQSFID EGDPYLSHIE ETVRLVMERF EGVTYHLAFQ SRAGPVKWLE 

       250        260        270        280        290        300 
PSTEEILEYL AAHQVKNLLM VPLSFVSDHI ETLHEIDIEY AMLAHRLGYA KFRRSPSLNT 

       310 
SPLFIDCLAD LVRKAGM

« Hide

References

[1]"Complete sequence of Geobacter metallireducens GS-15."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GS-15 / ATCC 53774 / DSM 7210.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000148 Genomic DNA. Translation: ABB30269.1.
RefSeqYP_382994.1. NC_007517.1.

3D structure databases

ProteinModelPortalQ39ZQ5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ39ZQ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3739921.
GenomeReviewsGene locus Gmet_0019 in contig CP000148_GR.
KEGGgme:Gmet_0019.
NMPDRfig|269799.3.peg.83.
PATRIC21999168. VBIGeoMet55070_0032.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALLQMGGP.
PhylomeDBQ39ZQ5.
ProtClustDBCLSK790160.

Enzyme and pathway databases

BioCycGMET269799:GMET_0019-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_GEOMG
AccessionPrimary (citable) accession number: Q39ZQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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