Q39Z89 (Q39Z89_GEOMG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

Gmet_0189

Organism

Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210) [Complete proteome] [HAMAP]

Taxonomic identifier

269799 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. PIRSR PIRSR001415-3 RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL ABB30435.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	195	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	248	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	120	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	122	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	130	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	233	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	205	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	217	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	274	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	313	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q39Z89 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 0C7EBCA2AD51F5A5	FASTA	325	36,333
	10 20 30 40 50 60 MFFPTFRARR IRGKEVFRRM VSETTLSATD LIYPMFSAFG TGIRKEISSM PGIYQQSIEH 70 80 90 100 110 120 IVAEAQEVYE LGVPAVILFG IPETKDAVGS DAYDEHGIIQ ETIRAIKKQV PGLAVITDVC 130 140 150 160 170 180 MCEYTDHGHC GIIKDGDVDN DETLELLAKE ALSHAEAGAD MVAPSDMMDG RVMAIREILD 190 200 210 220 230 240 NHGYKHIPIM SYAVKYASGY YGPFREAAES TPQFGDRRSY QMDPGNRREA VREARMDVEE 250 260 270 280 290 300 GADIIMVKPG LPYLDIVRDL REEFDLPVAV YNVSGEYSMI KAAGRAGWID EERVMMETLL 310 320 SFKRAGADLI LTYHAKEAAR VLKRG

References

[1]

"Complete sequence of Geobacter metallireducens GS-15." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GS-15 / ATCC 53774 / DSM 7210.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000148 Genomic DNA. Translation: ABB30435.1.
RefSeq	YP_383160.1. NC_007517.1.
3D structure databases
ProteinModelPortal	Q39Z89.
SMR	Q39Z89. Positions 6-323.
ModBase	Search...
Protein-protein interaction databases
STRING	Q39Z89.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3739073.
GenomeReviews	Gene locus Gmet_0189 in contig CP000148_GR.
KEGG	gme:Gmet_0189.
NMPDR	fig|269799.3.peg.220.
PATRIC	21999520. VBIGeoMet55070_0207.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0113.
HOGENOM	HBG285270.
OMA	ADLCFCE.
PhylomeDB	Q39Z89.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q39Z89_GEOMG

Accession

Primary (citable) accession number: Q39Z89

Entry history

Integrated into UniProtKB/TrEMBL:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)