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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGMET269799:GHNY-383-MONOMER.
UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotation
Ordered Locus Names:Gmet_0383
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000007073 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212ATP phosphoribosyltransferasePRO_0000229316Add
BLAST

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

Protein-protein interaction databases

STRINGi269799.Gmet_0383.

Structurei

3D structure databases

ProteinModelPortaliQ39YP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Lacks the C-terminal regulatory region which is replaced by HisZ.

Sequence similaritiesi

Belongs to the ATP phosphoribosyltransferase family. Short subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E21. Bacteria.
COG0040. LUCA.
HOGENOMiHOG000223248.
KOiK00765.
OMAiNPVSYRM.
OrthoDBiPOG091H05D7.

Family and domain databases

CDDicd13595. PBP2_HisGs. 1 hit.
HAMAPiMF_01018. HisG_Short. 1 hit.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PTHR21403:SF3. PTHR21403:SF3. 1 hit.
PfamiPF01634. HisG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00070. hisG. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39YP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFLTIAIP KGRILEESVA LFGKIGIHCD ELLSNTRKLI FENREQRMRY
60 70 80 90 100
MIVRATDVPT YVEYGCADLG IVGKDTLMEQ EKDLYEPLDL KFGYCRMMVA
110 120 130 140 150
EPAGLARDDD PSSWSNIRIA TKYPNVTEKY FAKKGVQVEI IKLYGSIELA
160 170 180 190 200
PLVGLSERIV DLVSTGETLR QNGLVEVETI AEITTRLIVN RASLKTKHPR
210
ITEIIEGLEK HV
Length:212
Mass (Da):23,963
Last modified:November 22, 2005 - v1
Checksum:i079AF683CCBF59A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB30626.1.
RefSeqiWP_004512355.1. NC_007517.1.

Genome annotation databases

EnsemblBacteriaiABB30626; ABB30626; Gmet_0383.
KEGGigme:Gmet_0383.
PATRICi21999914. VBIGeoMet55070_0404.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB30626.1.
RefSeqiWP_004512355.1. NC_007517.1.

3D structure databases

ProteinModelPortaliQ39YP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269799.Gmet_0383.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB30626; ABB30626; Gmet_0383.
KEGGigme:Gmet_0383.
PATRICi21999914. VBIGeoMet55070_0404.

Phylogenomic databases

eggNOGiENOG4105E21. Bacteria.
COG0040. LUCA.
HOGENOMiHOG000223248.
KOiK00765.
OMAiNPVSYRM.
OrthoDBiPOG091H05D7.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.
BioCyciGMET269799:GHNY-383-MONOMER.

Family and domain databases

CDDicd13595. PBP2_HisGs. 1 hit.
HAMAPiMF_01018. HisG_Short. 1 hit.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PTHR21403:SF3. PTHR21403:SF3. 1 hit.
PfamiPF01634. HisG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00070. hisG. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIS1_GEOMG
AccessioniPrimary (citable) accession number: Q39YP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.