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Q39YP6 (HIS8_GEOMG) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene names
Name:hisC
Ordered Locus Names:Gmet_0385
OrganismGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210) [Complete proteome] [HAMAP]
Taxonomic identifier269799 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_01023

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023

Subunit structure

Homodimer By similarity. HAMAP MF_01023

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Histidinol-phosphate aminotransferase HAMAP MF_01023
PRO_0000230215

Amino acid modifications

Modified residue2121N6-(pyridoxal phosphate)lysine By similarity

Secondary structure

1 ....................................................... 350
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q39YP6 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: C6158BFBB5051A99

FASTA35039,135
        10         20         30         40         50         60 
MIPLRQNIAS MKGYIPGYQP PDIASWIKLN TNENPYPPSP EVVKAILEEL GPDGAALRIY 

        70         80         90        100        110        120 
PSASSQKLRE VAGELYGFDP SWIIMANGSD EVLNNLIRAF AAEGEEIGYV HPSYSYYGTL 

       130        140        150        160        170        180 
AEVQGARVRT FGLTGDFRIA GFPERYEGKV FFLTTPNAPL GPSFPLEYID ELARRCAGML 

       190        200        210        220        230        240 
VLDETYAEFA ESNALELVRR HENVVVTRTL SKSYSLAGMR IGLAIARPEV IAALDKIRDH 

       250        260        270        280        290        300 
YNLDRLAQAA CVAALRDQAY LSECCRRIRE TREWFTTELR SIGYDVIPSQ GNYLFATPPD 

       310        320        330        340        350 
RDGKRVYDGL YARKVLVRHF SDPLLAHGMR ISIGTREEME QTLAALKEIG

« Hide

References

[1]"Complete sequence of Geobacter metallireducens GS-15."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GS-15 / ATCC 53774 / DSM 7210.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000148 Genomic DNA. Translation: ABB30628.1.
RefSeqYP_383353.1. NC_007517.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3HDOX-ray1.61A/B2-350[»]
ProteinModelPortalQ39YP6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ39YP6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3739751.
GenomeReviewsGene locus Gmet_0385 in contig CP000148_GR.
KEGGgme:Gmet_0385.
NMPDRfig|269799.3.peg.397.
PATRIC21999918. VBIGeoMet55070_0406.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0079.
HOGENOMHBG646350.
OMAMKNSFNS.
PhylomeDBQ39YP6.
ProtClustDBCLSK829109.

Enzyme and pathway databases

BioCycGMET269799:GMET_0385-MONOMER.

Family and domain databases

HAMAPMF_01023. HisC_aminotrans_2.
[Tree]
InterProIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00817.
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01141. HisC. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS8_GEOMG
AccessionPrimary (citable) accession number: Q39YP6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 22, 2005
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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