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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei318Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCobalamin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00061; UER00516

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:Gmet_0467
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000007073 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000215971 – 353Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseAdd BLAST353

Proteomic databases

PRIDEiQ39YG4

Interactioni

Protein-protein interaction databases

STRINGi269799.Gmet_0467

Structurei

3D structure databases

ProteinModelPortaliQ39YG4
SMRiQ39YG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUP Bacteria
COG2038 LUCA
HOGENOMiHOG000263499
KOiK00768
OMAiATFGGFE
OrthoDBiPOG091H0031

Family and domain databases

CDDicd02439 DMB-PRT_CobT, 1 hit
Gene3Di1.10.1610.10, 2 hits
HAMAPiMF_00230 CobT, 1 hit
InterProiView protein in InterPro
IPR003200 Nict_dMeBzImd_PRibTrfase-like
IPR023195 Nict_dMeBzImd_PRibTrfase_N
IPR017846 Nict_dMeBzImd_PRibTrfase_pro
IPR036087 Nict_dMeBzImd_PRibTrfase_sf
PfamiView protein in Pfam
PF02277 DBI_PRT, 1 hit
SUPFAMiSSF52733 SSF52733, 1 hit
TIGRFAMsiTIGR03160 cobT_DBIPRT, 1 hit

Sequencei

Sequence statusi: Complete.

Q39YG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLLTETLSN IRPVDAGLMA QAQARLDNKT KPIGSLGRLE EFARRTVAIS
60 70 80 90 100
GSLDPSTAKK AIFTFAADHG VVEEGVSAFP KEVTVQMVFN FLKGGAGINV
110 120 130 140 150
LANHVGADVL VVDMGIDHDF GDTPGLIDRK VARGTRNMAK GPAMTREEAV
160 170 180 190 200
TALEAGIELA CGCKADGVAM AGTGEMGIGN TTAASAIIAA FSGKTVADVT
210 220 230 240 250
HRGTGINDAA LAKKVTIIEQ ALAVNRPDPK DPIDVLAKVG GLEIAGIAGL
260 270 280 290 300
VLGCAANRIP VVVDGFISTA GALIACELCP TVKEYIFAAH ESVEIGHRFM
310 320 330 340 350
LERIGAEPIL DLHLRLGEGT GAALAMGLIE AGVKILKEMA TFAEAGVEKG

RDQ
Length:353
Mass (Da):36,518
Last modified:November 22, 2005 - v1
Checksum:iCCB55A3C201A5CFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA Translation: ABB30710.1
RefSeqiWP_004513836.1, NC_007517.1

Genome annotation databases

EnsemblBacteriaiABB30710; ABB30710; Gmet_0467
KEGGigme:Gmet_0467

Similar proteinsi

Entry informationi

Entry nameiCOBT_GEOMG
AccessioniPrimary (citable) accession number: Q39YG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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