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Protein

Glucose-1-phosphate thymidylyltransferase

Gene

rmlA

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.UniRule annotation

Catalytic activityi

dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciGMET269799:GHNY-932-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate thymidylyltransferaseUniRule annotation (EC:2.7.7.24UniRule annotation)
Gene namesi
Name:rmlAImported
Ordered Locus Names:Gmet_0924Imported
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)Imported
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007073 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi269799.Gmet_0924.

Structurei

3D structure databases

ProteinModelPortaliQ39X58.
SMRiQ39X58. Positions 1-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-1-phosphate thymidylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1209.
HOGENOMiHOG000283473.
KOiK00973.
OMAiPHDAEQF.
OrthoDBiEOG6RC3RN.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005907. G1P_thy_trans_s.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22572:SF13. PTHR22572:SF13. 1 hit.
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01207. rmlA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39X58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKKGIILA GGAGSRLYPL TLVASKQLQP VYDKPMIYYP LATLMMAGIS
60 70 80 90 100
DILIISTPHD TPRFQSLLGD GSRWGIRLTY KVQPEPKGIA QAFLVGEEFI
110 120 130 140 150
AGDPVCLILG DNIFYGKMGL DRAIRDFAGG ALVFGYYVND PERYGVVQFD
160 170 180 190 200
GSGKAIGIEE KPAAPKSNYA VPGLYLYDGK VSEIARNLAP SARGELEITD
210 220 230 240 250
VNLEYLRRGE LMVEKLGRGI AWLDTGTHQS LLEASHFIGT LEARQGLKIA
260 270 280 290 300
CLEEIALRMG YIDCRKMAEV IAATPNSSYR EYLVRVHNET NLCGGHDDAK

LS
Length:302
Mass (Da):33,034
Last modified:November 22, 2005 - v1
Checksum:i1469C387E0C08425
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB31166.1.
RefSeqiWP_004513954.1. NC_007517.1.

Genome annotation databases

EnsemblBacteriaiABB31166; ABB31166; Gmet_0924.
KEGGigme:Gmet_0924.
PATRICi22001036. VBIGeoMet55070_0959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB31166.1.
RefSeqiWP_004513954.1. NC_007517.1.

3D structure databases

ProteinModelPortaliQ39X58.
SMRiQ39X58. Positions 1-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269799.Gmet_0924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB31166; ABB31166; Gmet_0924.
KEGGigme:Gmet_0924.
PATRICi22001036. VBIGeoMet55070_0959.

Phylogenomic databases

eggNOGiCOG1209.
HOGENOMiHOG000283473.
KOiK00973.
OMAiPHDAEQF.
OrthoDBiEOG6RC3RN.

Enzyme and pathway databases

BioCyciGMET269799:GHNY-932-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005907. G1P_thy_trans_s.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22572:SF13. PTHR22572:SF13. 1 hit.
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01207. rmlA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Geobacter metallireducens GS-15."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS-15 / ATCC 53774 / DSM 7210Imported.

Entry informationi

Entry nameiQ39X58_GEOMG
AccessioniPrimary (citable) accession number: Q39X58
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 22, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.