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Q39X41

- NADK_GEOMG

UniProt

Q39X41 - NADK_GEOMG

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Protein

NAD kinase

Gene

nadK

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Proton acceptorUniRule annotation
Binding sitei151 – 1511NADUniRule annotation
Binding sitei168 – 1681NADUniRule annotation
Binding sitei170 – 1701NADUniRule annotation
Binding sitei240 – 2401NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 672NADUniRule annotation
Nucleotide bindingi140 – 1412NADUniRule annotation
Nucleotide bindingi181 – 1866NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciGMET269799:GHNY-949-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Gmet_0941
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007073: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283NAD kinasePRO_0000229639Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269799.Gmet_0941.

Structurei

3D structure databases

ProteinModelPortaliQ39X41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiGAEFCLN.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39X41-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIAIFAKV HDPRCQGVAG ELITWLEQRR IVPLVEAHFA RHLGRSGVTS
60 70 80 90 100
EEIPDLADMA VVLGGDGTLI SAARLLGGRE IPILGVNLGS LGFLTEVTLD
110 120 130 140 150
ELYPALEACL GGDYRVSERM MLAATVERGD DIVFSHRVLN DAVINKGALA
160 170 180 190 200
RIVDMESLVN GHYLTTYKAD GLIISTPTGS TGYCLSANGP IVHPDLECLT
210 220 230 240 250
ITPICPHTLT NRPIVLEASA EVTIRLISKN EDVYLTLDGQ VGMELKCGDI
260 270 280
IRVRRAEHRT RLVMSRSKDY FEVLRTKLKW GER
Length:283
Mass (Da):31,071
Last modified:November 22, 2005 - v1
Checksum:iC297788A90E10533
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000148 Genomic DNA. Translation: ABB31183.1.
RefSeqiWP_004514424.1. NC_007517.1.
YP_006719908.1. NC_007517.1.

Genome annotation databases

EnsemblBacteriaiABB31183; ABB31183; Gmet_0941.
GeneIDi3738511.
KEGGigme:Gmet_0941.
PATRICi22001072. VBIGeoMet55070_0977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000148 Genomic DNA. Translation: ABB31183.1 .
RefSeqi WP_004514424.1. NC_007517.1.
YP_006719908.1. NC_007517.1.

3D structure databases

ProteinModelPortali Q39X41.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269799.Gmet_0941.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB31183 ; ABB31183 ; Gmet_0941 .
GeneIDi 3738511.
KEGGi gme:Gmet_0941.
PATRICi 22001072. VBIGeoMet55070_0977.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi GAEFCLN.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci GMET269799:GHNY-949-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Geobacter metallireducens GS-15."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS-15 / ATCC 53774 / DSM 7210.

Entry informationi

Entry nameiNADK_GEOMG
AccessioniPrimary (citable) accession number: Q39X41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3