Q39VQ6 (SYR_GEOMG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	Gmet_1434

Organism

Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210) [Complete proteome] [HAMAP]

Taxonomic identifier

269799 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter › Geobacter metallireducens

Protein attributes

Sequence length	562 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.
Sequence caution	The sequence ABB31668.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 562	562	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_0000242026
Regions
	Motif	130 – 140	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q39VQ6 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 04F8CEB87823CC87	FASTA	562	62,252
	10 20 30 40 50 60 MKDRVRSLVA EGIERCFADG SLASNQMPAI VIEKPAHAEH GDFACTVAMS MAKAERKAPR 70 80 90 100 110 120 VIAETIVKHI ENGESGIIGG IDIAGPGFIN FRIKNEAWSR TLAVVEAAGA SFGRSCAGEE 130 140 150 160 170 180 RKVQVEFVSA NPTGPLHIGH GRGAAIGDTI CRLLSASGFD VTREFYYNDA GAQIANLALS 190 200 210 220 230 240 VQSRCLGIEP GDPRWPADGY QGDYIKDVAR SYLNRETVDA GDQHVTAAGD PNDLDAIRRF 250 260 270 280 290 300 AVAYLRREQD QDLLAFDVHF DVYSLESSLY TEGRVEEVVR RLIENGHTFE QDGALWLRTT 310 320 330 340 350 360 DFGDDKDRVM RKSDGSYTYF VPDVAYHLAK WERGFTRVIN EQGADHHSTI TRVRAGLQAL 370 380 390 400 410 420 NAGIPQEWPE YVLHQMVTVM RGGEEVKISK RAGSYVTLRD LIDEVGRDAT RFFFLMRKPD 430 440 450 460 470 480 SQLVFDIDLA KQQSLENPVY YVQYAHARIS SIFEAACDRG ISVPSFPDAH VDLLETPEEI 490 500 510 520 530 540 ELIKLIGSFP EVIEGSALSF EPHRITYYLQ ELAGAFHSFY NKNRVIGEGK ELSSARLFLL 550 560 KGVAQVLKNG LALLGVSAPE KM

References

[1]

"Complete sequence of Geobacter metallireducens GS-15." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GS-15 / ATCC 53774 / DSM 7210.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000148 Genomic DNA. Translation: ABB31668.1. Different initiation.
RefSeq	YP_006720400.1. NC_007517.1.
3D structure databases
ProteinModelPortal	Q39VQ6.
ModBase	Search...
Protein-protein interaction databases
STRING	269799.Gmet_1434.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB31668; ABB31668; Gmet_1434.
GeneID	3738564.
KEGG	gme:Gmet_1434.
PATRIC	22002084. VBIGeoMet55070_1470.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HOG000247214.
KO	K01887.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	GMET269799:GHNY-1456-MONOMER.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_GEOMG

Accession

Primary (citable) accession number: Q39VQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	May 1, 2013
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program