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Q39V66

- RISB_GEOMG

UniProt

Q39V66 - RISB_GEOMG

Protein

6,7-dimethyl-8-ribityllumazine synthase

Gene

ribH

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.UniRule annotation

    Catalytic activityi

    1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei23 – 2315-amino-6-(D-ribitylamino)uracilUniRule annotation
    Active sitei89 – 891Proton donorUniRule annotation
    Binding sitei114 – 11415-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei128 – 12811-deoxy-L-glycero-tetrulose 4-phosphateUniRule annotation

    GO - Molecular functioni

    1. 6,7-dimethyl-8-ribityllumazine synthase activity Source: UniProtKB-HAMAP
    2. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Enzyme and pathway databases

    BioCyciGMET269799:GHNY-1652-MONOMER.
    UniPathwayiUPA00275; UER00404.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6,7-dimethyl-8-ribityllumazine synthaseUniRule annotation (EC:2.5.1.78UniRule annotation)
    Short name:
    DMRL synthaseUniRule annotation
    Short name:
    LSUniRule annotation
    Short name:
    Lumazine synthaseUniRule annotation
    Gene namesi
    Name:ribHUniRule annotation
    Ordered Locus Names:Gmet_1627
    OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
    Taxonomic identifieri269799 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000007073: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. riboflavin synthase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1551556,7-dimethyl-8-ribityllumazine synthasePRO_1000040424Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269799.Gmet_1627.

    Structurei

    3D structure databases

    ProteinModelPortaliQ39V66.
    SMRiQ39V66. Positions 5-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 5935-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
    Regioni81 – 8335-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
    Regioni86 – 8721-deoxy-L-glycero-tetrulose 4-phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DMRL synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0054.
    HOGENOMiHOG000229249.
    KOiK00794.
    OMAiIEMANLS.
    OrthoDBiEOG6RC3WC.

    Family and domain databases

    Gene3Di3.40.50.960. 1 hit.
    HAMAPiMF_00178. Lumazine_synth.
    InterProiIPR002180. DMRL_synthase.
    [Graphical view]
    PANTHERiPTHR21058. PTHR21058. 1 hit.
    PfamiPF00885. DMRL_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52121. SSF52121. 1 hit.
    TIGRFAMsiTIGR00114. lumazine-synth. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q39V66-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRFIEGKLD ATGLKFGIIV GRFNSFIGER LLEGALDALV RNGADEATID    50
    VARVPGAFEI PLTAKKMAQT GSYDAIICLG AVIRGSTPHF DYVAAEVSKG 100
    VAHVSLETGV PVSFGVLTTD TIEQAVERAG TKAGNKGFDA AMTAIETVRV 150
    FREFR 155
    Length:155
    Mass (Da):16,462
    Last modified:November 22, 2005 - v1
    Checksum:i53573BDD63670235
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000148 Genomic DNA. Translation: ABB31858.1.
    RefSeqiYP_006720594.1. NC_007517.1.

    Genome annotation databases

    EnsemblBacteriaiABB31858; ABB31858; Gmet_1627.
    GeneIDi3739366.
    KEGGigme:Gmet_1627.
    PATRICi22002478. VBIGeoMet55070_1665.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000148 Genomic DNA. Translation: ABB31858.1 .
    RefSeqi YP_006720594.1. NC_007517.1.

    3D structure databases

    ProteinModelPortali Q39V66.
    SMRi Q39V66. Positions 5-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269799.Gmet_1627.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB31858 ; ABB31858 ; Gmet_1627 .
    GeneIDi 3739366.
    KEGGi gme:Gmet_1627.
    PATRICi 22002478. VBIGeoMet55070_1665.

    Phylogenomic databases

    eggNOGi COG0054.
    HOGENOMi HOG000229249.
    KOi K00794.
    OMAi IEMANLS.
    OrthoDBi EOG6RC3WC.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00404 .
    BioCyci GMET269799:GHNY-1652-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.960. 1 hit.
    HAMAPi MF_00178. Lumazine_synth.
    InterProi IPR002180. DMRL_synthase.
    [Graphical view ]
    PANTHERi PTHR21058. PTHR21058. 1 hit.
    Pfami PF00885. DMRL_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52121. SSF52121. 1 hit.
    TIGRFAMsi TIGR00114. lumazine-synth. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Geobacter metallireducens GS-15."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GS-15 / ATCC 53774 / DSM 7210.

    Entry informationi

    Entry nameiRISB_GEOMG
    AccessioniPrimary (citable) accession number: Q39V66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3