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Q39V66

- RISB_GEOMG

UniProt

Q39V66 - RISB_GEOMG

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Protein
6,7-dimethyl-8-ribityllumazine synthase
Gene
ribH, Gmet_1627
Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin By similarity.UniRule annotation

Catalytic activityi

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei23 – 2315-amino-6-(D-ribitylamino)uracil By similarity
Active sitei89 – 891Proton donor Reviewed prediction
Binding sitei114 – 11415-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei128 – 12811-deoxy-L-glycero-tetrulose 4-phosphate By similarity

GO - Molecular functioni

  1. 6,7-dimethyl-8-ribityllumazine synthase activity Source: UniProtKB-HAMAP
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Enzyme and pathway databases

BioCyciGMET269799:GHNY-1652-MONOMER.
UniPathwayiUPA00275; UER00404.

Names & Taxonomyi

Protein namesi
Recommended name:
6,7-dimethyl-8-ribityllumazine synthase (EC:2.5.1.78)
Short name:
DMRL synthase
Short name:
LS
Short name:
Lumazine synthase
Gene namesi
Name:ribH
Ordered Locus Names:Gmet_1627
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007073: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. riboflavin synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1551556,7-dimethyl-8-ribityllumazine synthaseUniRule annotation
PRO_1000040424Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269799.Gmet_1627.

Structurei

3D structure databases

ProteinModelPortaliQ39V66.
SMRiQ39V66. Positions 5-154.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 5935-amino-6-(D-ribitylamino)uracil binding By similarity
Regioni81 – 8335-amino-6-(D-ribitylamino)uracil binding By similarity
Regioni86 – 8721-deoxy-L-glycero-tetrulose 4-phosphate binding By similarity

Sequence similaritiesi

Belongs to the DMRL synthase family.

Phylogenomic databases

eggNOGiCOG0054.
HOGENOMiHOG000229249.
KOiK00794.
OMAiIEMANLS.
OrthoDBiEOG6RC3WC.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
HAMAPiMF_00178. Lumazine_synth.
InterProiIPR002180. DMRL_synthase.
[Graphical view]
PANTHERiPTHR21058. PTHR21058. 1 hit.
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR00114. lumazine-synth. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39V66-1 [UniParc]FASTAAdd to Basket

« Hide

MPRFIEGKLD ATGLKFGIIV GRFNSFIGER LLEGALDALV RNGADEATID    50
VARVPGAFEI PLTAKKMAQT GSYDAIICLG AVIRGSTPHF DYVAAEVSKG 100
VAHVSLETGV PVSFGVLTTD TIEQAVERAG TKAGNKGFDA AMTAIETVRV 150
FREFR 155
Length:155
Mass (Da):16,462
Last modified:November 22, 2005 - v1
Checksum:i53573BDD63670235
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000148 Genomic DNA. Translation: ABB31858.1.
RefSeqiYP_006720594.1. NC_007517.1.

Genome annotation databases

EnsemblBacteriaiABB31858; ABB31858; Gmet_1627.
GeneIDi3739366.
KEGGigme:Gmet_1627.
PATRICi22002478. VBIGeoMet55070_1665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000148 Genomic DNA. Translation: ABB31858.1 .
RefSeqi YP_006720594.1. NC_007517.1.

3D structure databases

ProteinModelPortali Q39V66.
SMRi Q39V66. Positions 5-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269799.Gmet_1627.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB31858 ; ABB31858 ; Gmet_1627 .
GeneIDi 3739366.
KEGGi gme:Gmet_1627.
PATRICi 22002478. VBIGeoMet55070_1665.

Phylogenomic databases

eggNOGi COG0054.
HOGENOMi HOG000229249.
KOi K00794.
OMAi IEMANLS.
OrthoDBi EOG6RC3WC.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00404 .
BioCyci GMET269799:GHNY-1652-MONOMER.

Family and domain databases

Gene3Di 3.40.50.960. 1 hit.
HAMAPi MF_00178. Lumazine_synth.
InterProi IPR002180. DMRL_synthase.
[Graphical view ]
PANTHERi PTHR21058. PTHR21058. 1 hit.
Pfami PF00885. DMRL_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF52121. SSF52121. 1 hit.
TIGRFAMsi TIGR00114. lumazine-synth. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Geobacter metallireducens GS-15."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS-15 / ATCC 53774 / DSM 7210.

Entry informationi

Entry nameiRISB_GEOMG
AccessioniPrimary (citable) accession number: Q39V66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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