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Q39V17

- GLPK_GEOMG

UniProt

Q39V17 - GLPK_GEOMG

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Protein
Glycerol kinase
Gene
glpK, Gmet_1676
Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP) By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei15 – 151ATP By similarity
Binding sitei133 – 1331Substrate By similarity
Binding sitei264 – 2641ATP By similarity
Binding sitei307 – 3071ATP; via carbonyl oxygen By similarity
Binding sitei311 – 3111ATP; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 133ATP By similarity
Nucleotide bindingi408 – 4125ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycerol kinase activity Source: UniProtKB

GO - Biological processi

  1. glycerol catabolic process Source: UniProtKB-UniPathway
  2. glycerol metabolic process Source: UniProtKB
  3. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGMET269799:GHNY-1703-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase (EC:2.7.1.30)
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name:
GK
Gene namesi
Name:glpK
Ordered Locus Names:Gmet_1676
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007073: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Glycerol kinaseUniRule annotation
PRO_1000098734Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269799.Gmet_1676.

Structurei

3D structure databases

ProteinModelPortaliQ39V17.
SMRiQ39V17. Positions 3-494.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 822Substrate binding By similarity
Regioni242 – 2432Substrate binding By similarity

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG0554.
HOGENOMiHOG000222134.
KOiK00864.
OMAiHFFGVEV.
OrthoDBiEOG6RZB46.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39V17-1 [UniParc]FASTAAdd to Basket

« Hide

MSYILALDQG TTSSRAIVFD TTATIRAIAQ REFRQIFPRP GWVEHDGREI    50
WATQVGVAAE ALTRAGISPR EVRAIGITNQ RETTLLWDRR SGEPLHNAIV 100
WQDRRTAELC DRLKADGLEP LFRQKTGLVL DAYFSGTKLA WLLEAIPGAR 150
SRAEAGELAF GTVDSWLAWN LSGGKLHVTD ASNASRTLLF NITTLDWDDE 200
LLAILGIPRA VLPRVVDSGA VYGETAGDIF AAAIPLAGMA GDQQAALFGQ 250
ACGTAGMAKN TYGTGCFLLM HCGTRPIESR HNLLTTVAWQ LGGRAEYALE 300
GSVFVAGAAV QWLRDGLGII RSSGEVEALA ASVPDSGGVC LVPAFTGLGA 350
PHWDPYARGT IVGITRGTTA AHIARATLES IAFQSADLLT AMEADAGISL 400
AELRVDGGAT ANGLLMQFQA DLLGVPVVRP RISETTALGA AYLAGLAVGL 450
WRDRQEIAGH WQVDRIFEPA MGREQAAELR GRWGRAVERA RGWAAP 496
Length:496
Mass (Da):53,061
Last modified:November 22, 2005 - v1
Checksum:i715F4D77D0119A85
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000148 Genomic DNA. Translation: ABB31907.1.
RefSeqiYP_006720643.1. NC_007517.1.

Genome annotation databases

EnsemblBacteriaiABB31907; ABB31907; Gmet_1676.
GeneIDi3740526.
KEGGigme:Gmet_1676.
PATRICi22002580. VBIGeoMet55070_1715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000148 Genomic DNA. Translation: ABB31907.1 .
RefSeqi YP_006720643.1. NC_007517.1.

3D structure databases

ProteinModelPortali Q39V17.
SMRi Q39V17. Positions 3-494.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269799.Gmet_1676.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB31907 ; ABB31907 ; Gmet_1676 .
GeneIDi 3740526.
KEGGi gme:Gmet_1676.
PATRICi 22002580. VBIGeoMet55070_1715.

Phylogenomic databases

eggNOGi COG0554.
HOGENOMi HOG000222134.
KOi K00864.
OMAi HFFGVEV.
OrthoDBi EOG6RZB46.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci GMET269799:GHNY-1703-MONOMER.

Family and domain databases

HAMAPi MF_00186. Glycerol_kin.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Geobacter metallireducens GS-15."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS-15 / ATCC 53774 / DSM 7210.

Entry informationi

Entry nameiGLPK_GEOMG
AccessioniPrimary (citable) accession number: Q39V17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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