Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q39UH1 (TIG_GEOMG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trigger factor

Short name=TF
EC=5.2.1.8
Alternative name(s):
PPIase
Gene names
Name:tig
Ordered Locus Names:Gmet_1874
OrganismGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210) [Complete proteome] [HAMAP]
Taxonomic identifier269799 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity. HAMAP-Rule MF_00303

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0). HAMAP-Rule MF_00303

Subcellular location

Cytoplasm. Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm By similarity. HAMAP-Rule MF_00303

Domain

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own By similarity. HAMAP-Rule MF_00303

Sequence similarities

Belongs to the FKBP-type PPIase family. Tig subfamily.

Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
   Cellular componentCytoplasm
   Molecular functionChaperone
Isomerase
Rotamase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

protein folding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

protein transport

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Trigger factor HAMAP-Rule MF_00303
PRO_0000256562

Regions

Domain163 – 24886PPIase FKBP-type

Sequences

Sequence LengthMass (Da)Tools
Q39UH1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 94547EB2ED7B4F23

FASTA43348,639
        10         20         30         40         50         60 
MTSTVESLSS VKKKISFEIP AERVSAEIEK VFGQIQKRAA IKGFRKGKVP RSLVEQNYRS 

        70         80         90        100        110        120 
MMESDVLKNL FDETYFKALA DHKIFPVSHP HIESDEVKRG EALKYSATVE VFPEIDVKDY 

       130        140        150        160        170        180 
KGLEVKRERF VSDVAPVEAR LNEMREGMAE LKPLEEGKCA ETGNFVVIDF VGSVDGIPFE 

       190        200        210        220        230        240 
GGAAESYQLE LGSGRFIPGF EDQLVGVKAG EQRTVEVTFP EEYGNKDLAG KAASFAVTVK 

       250        260        270        280        290        300 
EAKVKELPEL DDEFAMQFGE FETLEQLKTK LAELHKDQET ARIKADVQDR IVKALIGNNE 

       310        320        330        340        350        360 
IEVPSTLVER QLQMMLSNMK NRLAQQRLSL EMMGMDDESF KTHYRDSAES QVKGSLLLEA 

       370        380        390        400        410        420 
VAKKEGITVN DPDVEAKLRA MAEEAGQDFD RVKDFYEQNH NAKENLVAHL NEEKVLGYLL 

       430 
ENAVVTEVAK DEL 

« Hide

References

[1]"Complete sequence of Geobacter metallireducens GS-15."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GS-15 / ATCC 53774 / DSM 7210.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000148 Genomic DNA. Translation: ABB32103.1.
RefSeqYP_006720837.1. NC_007517.1.

3D structure databases

ProteinModelPortalQ39UH1.
SMRQ39UH1. Positions 149-251.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING269799.Gmet_1874.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB32103; ABB32103; Gmet_1874.
GeneID3740272.
KEGGgme:Gmet_1874.
PATRIC22002990. VBIGeoMet55070_1916.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0544.
HOGENOMHOG000218240.
KOK03545.
OMAFKVKVHE.
OrthoDBEOG63VBX3.

Enzyme and pathway databases

BioCycGMET269799:GHNY-1905-MONOMER.

Family and domain databases

Gene3D1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPMF_00303. Trigger_factor_Tig.
InterProIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFPIRSF003095. Trigger_factor. 1 hit.
SUPFAMSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsTIGR00115. tig. 1 hit.
PROSITEPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTIG_GEOMG
AccessionPrimary (citable) accession number: Q39UH1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families