Q39UH1 (TIG_GEOMG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trigger factor
Short name=TF
EC=5.2.1.8

Alternative name(s):
PPIase

Gene names

Name:	tig
Ordered Locus Names:	Gmet_1874

Organism

Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210) [Complete proteome] [HAMAP]

Taxonomic identifier

269799 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter › Geobacter metallireducens

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity. HAMAP-Rule MF_00303
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0). HAMAP-Rule MF_00303
Subcellular location	Cytoplasm. Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm By similarity. HAMAP-Rule MF_00303
Domain	Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own By similarity. HAMAP-Rule MF_00303
Sequence similarities	Belongs to the FKBP-type PPIase family. Tig subfamily. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm
Molecular function	Chaperone Isomerase Rotamase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW protein folding Inferred from electronic annotation. Source: HAMAP protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC protein transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Trigger factor HAMAP-Rule MF_00303		PRO_0000256562
Regions
	Domain	163 – 248	86	PPIase FKBP-type

Sequences

	Sequence		Length	Mass (Da)
	Q39UH1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 94547EB2ED7B4F23	FASTA	433	48,639
	10 20 30 40 50 60 MTSTVESLSS VKKKISFEIP AERVSAEIEK VFGQIQKRAA IKGFRKGKVP RSLVEQNYRS 70 80 90 100 110 120 MMESDVLKNL FDETYFKALA DHKIFPVSHP HIESDEVKRG EALKYSATVE VFPEIDVKDY 130 140 150 160 170 180 KGLEVKRERF VSDVAPVEAR LNEMREGMAE LKPLEEGKCA ETGNFVVIDF VGSVDGIPFE 190 200 210 220 230 240 GGAAESYQLE LGSGRFIPGF EDQLVGVKAG EQRTVEVTFP EEYGNKDLAG KAASFAVTVK 250 260 270 280 290 300 EAKVKELPEL DDEFAMQFGE FETLEQLKTK LAELHKDQET ARIKADVQDR IVKALIGNNE 310 320 330 340 350 360 IEVPSTLVER QLQMMLSNMK NRLAQQRLSL EMMGMDDESF KTHYRDSAES QVKGSLLLEA 370 380 390 400 410 420 VAKKEGITVN DPDVEAKLRA MAEEAGQDFD RVKDFYEQNH NAKENLVAHL NEEKVLGYLL 430 ENAVVTEVAK DEL

References

[1]

"Complete sequence of Geobacter metallireducens GS-15." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GS-15 / ATCC 53774 / DSM 7210.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000148 Genomic DNA. Translation: ABB32103.1.
RefSeq	YP_006720837.1. NC_007517.1.
3D structure databases
ProteinModelPortal	Q39UH1.
SMR	Q39UH1. Positions 149-251.
ModBase	Search...
Protein-protein interaction databases
STRING	269799.Gmet_1874.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB32103; ABB32103; Gmet_1874.
GeneID	3740272.
KEGG	gme:Gmet_1874.
PATRIC	22002990. VBIGeoMet55070_1916.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0544.
HOGENOM	HOG000218240.
KO	K03545.
OMA	FPADYHG.
ProtClustDB	CLSK828562.
Enzyme and pathway databases
BioCyc	GMET269799:GHNY-1903-MONOMER.
Family and domain databases
Gene3D	1.10.3120.10. 1 hit. 3.30.70.1050. 1 hit.
HAMAP	MF_00303. Trigger_factor_Tig.
InterPro	IPR001179. PPIase_FKBP_dom. IPR005215. Trig_fac. IPR008880. Trigger_fac_C. IPR008881. Trigger_fac_ribosome-bd_bac. IPR027304. Trigger_fact/SurA_dom. [Graphical view]
Pfam	PF00254. FKBP_C. 1 hit. PF05698. Trigger_C. 1 hit. PF05697. Trigger_N. 1 hit. [Graphical view]
PIRSF	PIRSF003095. Trigger_factor. 1 hit.
SUPFAM	SSF109998. Trigger_fac_C_bac. 1 hit. SSF102735. Trigger_fac_ribosome-bd_bac. 1 hit.
TIGRFAMs	TIGR00115. tig. 1 hit.
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TIG_GEOMG

Accession

Primary (citable) accession number: Q39UH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program