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Q39UH1

- TIG_GEOMG

UniProt

Q39UH1 - TIG_GEOMG

Protein

Trigger factor

Gene

tig

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein folding Source: UniProtKB-HAMAP
    4. protein transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone, Isomerase, Rotamase

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    BioCyciGMET269799:GHNY-1905-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
    Short name:
    TFUniRule annotation
    Alternative name(s):
    PPIaseUniRule annotation
    Gene namesi
    Name:tigUniRule annotation
    Ordered Locus Names:Gmet_1874
    OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
    Taxonomic identifieri269799 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000007073: Chromosome

    Subcellular locationi

    Cytoplasm
    Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Trigger factorPRO_0000256562Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269799.Gmet_1874.

    Structurei

    3D structure databases

    ProteinModelPortaliQ39UH1.
    SMRiQ39UH1. Positions 149-251.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini163 – 24886PPIase FKBP-typeUniRule annotationAdd
    BLAST

    Domaini

    Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation
    Contains 1 PPIase FKBP-type domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0544.
    HOGENOMiHOG000218240.
    KOiK03545.
    OMAiFKVKVHE.
    OrthoDBiEOG63VBX3.

    Family and domain databases

    Gene3Di1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPiMF_00303. Trigger_factor_Tig.
    InterProiIPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view]
    PfamiPF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003095. Trigger_factor. 1 hit.
    SUPFAMiSSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsiTIGR00115. tig. 1 hit.
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q39UH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSTVESLSS VKKKISFEIP AERVSAEIEK VFGQIQKRAA IKGFRKGKVP    50
    RSLVEQNYRS MMESDVLKNL FDETYFKALA DHKIFPVSHP HIESDEVKRG 100
    EALKYSATVE VFPEIDVKDY KGLEVKRERF VSDVAPVEAR LNEMREGMAE 150
    LKPLEEGKCA ETGNFVVIDF VGSVDGIPFE GGAAESYQLE LGSGRFIPGF 200
    EDQLVGVKAG EQRTVEVTFP EEYGNKDLAG KAASFAVTVK EAKVKELPEL 250
    DDEFAMQFGE FETLEQLKTK LAELHKDQET ARIKADVQDR IVKALIGNNE 300
    IEVPSTLVER QLQMMLSNMK NRLAQQRLSL EMMGMDDESF KTHYRDSAES 350
    QVKGSLLLEA VAKKEGITVN DPDVEAKLRA MAEEAGQDFD RVKDFYEQNH 400
    NAKENLVAHL NEEKVLGYLL ENAVVTEVAK DEL 433
    Length:433
    Mass (Da):48,639
    Last modified:November 22, 2005 - v1
    Checksum:i94547EB2ED7B4F23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000148 Genomic DNA. Translation: ABB32103.1.
    RefSeqiYP_006720837.1. NC_007517.1.

    Genome annotation databases

    EnsemblBacteriaiABB32103; ABB32103; Gmet_1874.
    GeneIDi3740272.
    KEGGigme:Gmet_1874.
    PATRICi22002990. VBIGeoMet55070_1916.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000148 Genomic DNA. Translation: ABB32103.1 .
    RefSeqi YP_006720837.1. NC_007517.1.

    3D structure databases

    ProteinModelPortali Q39UH1.
    SMRi Q39UH1. Positions 149-251.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269799.Gmet_1874.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB32103 ; ABB32103 ; Gmet_1874 .
    GeneIDi 3740272.
    KEGGi gme:Gmet_1874.
    PATRICi 22002990. VBIGeoMet55070_1916.

    Phylogenomic databases

    eggNOGi COG0544.
    HOGENOMi HOG000218240.
    KOi K03545.
    OMAi FKVKVHE.
    OrthoDBi EOG63VBX3.

    Enzyme and pathway databases

    BioCyci GMET269799:GHNY-1905-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPi MF_00303. Trigger_factor_Tig.
    InterProi IPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view ]
    Pfami PF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003095. Trigger_factor. 1 hit.
    SUPFAMi SSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsi TIGR00115. tig. 1 hit.
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Geobacter metallireducens GS-15."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GS-15 / ATCC 53774 / DSM 7210.

    Entry informationi

    Entry nameiTIG_GEOMG
    AccessioniPrimary (citable) accession number: Q39UH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3