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Q39T99

- SYL_GEOMG

UniProt

Q39T99 - SYL_GEOMG

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGMET269799:GHNY-2339-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Gmet_2300
    OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
    Taxonomic identifieri269799 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000007073: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 824824Leucine--tRNA ligasePRO_1000009346Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269799.Gmet_2300.

    Structurei

    3D structure databases

    ProteinModelPortaliQ39T99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi581 – 5855"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q39T99-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEKYIPRNV EEKWQKIWEE NKTYKVTEDP SKPKYYLLEM FPYPSGRIHM    50
    GHVRNYSIGD VVGRFKRLRG FNVLHPMGWD AFGMPAENAA IQHKSHPAKW 100
    TYENIAYMRS QLKKMGLSYD WDRELATCDL DYYKWEQKVF LEMYEKGLAY 150
    KKTSYVNWCP KCETVLANEQ VEDGACWRCD SEVTQKELEQ WFFRITDYAE 200
    ELLEYTEKLP GWPERVLTMQ RNWIGKSYGC EIDFPVEGSL AKIKVFTTRQ 250
    DTLYGATFMS LAPEHPMALE LTTPDRRAEV EAFIDKVKKT DKIKRTAEDF 300
    EKEGVFTGSY CINPVTNRRM PVFLANFVLL DYGTGAVMAV PTHDQRDFEF 350
    ARKYDLPLQV VIQPEGETLD PAAMATAYTE VGTMVNSGTF DGLRSDEAKE 400
    KIADYLAKEG IGTKTVNFRL RDWGISRQRY WGNPIPVIYC DICGVVPVPE 450
    KDLPVVLPMD VEFTGEGGSP LKKLDSFVNV PCPQCGQMAR RETDTMDTFV 500
    QSSWYFLRYC CPDFAAGPID KARAEYWMSV DQYIGGIEHA VLHLLYARFF 550
    TKALRDLGYV TVDEPFTNLL TQGMVIKDGA KMSKSKGNVV DPDALINRYG 600
    ADTARLFSLF AAPPEKDLDW SDQGVDGSYR FLSRVWRLVC DLLPFVGKGG 650
    AVDSASLSDD ARGLRRAVHK TIRKVTDDID ERFHFNTAIA AIMELVNAIY 700
    AFEPKNAPEN GPVLTEAIES VVIMLSPFVP HVTEELWEAL GHQGGVEAAG 750
    WPSFDPSAAV DEEFLIVVQV NGKLRGKVTV ATDATEEQVK AAAFADEKVK 800
    PWIEGKQLRK AIYVPGKLLN IVVG 824
    Length:824
    Mass (Da):93,514
    Last modified:November 22, 2005 - v1
    Checksum:i63EB85F98765DD2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000148 Genomic DNA. Translation: ABB32525.1.
    RefSeqiWP_004514498.1. NC_007517.1.
    YP_006721261.1. NC_007517.1.

    Genome annotation databases

    EnsemblBacteriaiABB32525; ABB32525; Gmet_2300.
    GeneIDi3739328.
    KEGGigme:Gmet_2300.
    PATRICi22003856. VBIGeoMet55070_2341.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000148 Genomic DNA. Translation: ABB32525.1 .
    RefSeqi WP_004514498.1. NC_007517.1.
    YP_006721261.1. NC_007517.1.

    3D structure databases

    ProteinModelPortali Q39T99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269799.Gmet_2300.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB32525 ; ABB32525 ; Gmet_2300 .
    GeneIDi 3739328.
    KEGGi gme:Gmet_2300.
    PATRICi 22003856. VBIGeoMet55070_2341.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci GMET269799:GHNY-2339-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Geobacter metallireducens GS-15."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GS-15 / ATCC 53774 / DSM 7210.

    Entry informationi

    Entry nameiSYL_GEOMG
    AccessioniPrimary (citable) accession number: Q39T99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3