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Q39T99

- SYL_GEOMG

UniProt

Q39T99 - SYL_GEOMG

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGMET269799:GHNY-2339-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Gmet_2300
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007073: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Leucine--tRNA ligasePRO_1000009346Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269799.Gmet_2300.

Structurei

3D structure databases

ProteinModelPortaliQ39T99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi581 – 5855"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39T99-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEKYIPRNV EEKWQKIWEE NKTYKVTEDP SKPKYYLLEM FPYPSGRIHM
60 70 80 90 100
GHVRNYSIGD VVGRFKRLRG FNVLHPMGWD AFGMPAENAA IQHKSHPAKW
110 120 130 140 150
TYENIAYMRS QLKKMGLSYD WDRELATCDL DYYKWEQKVF LEMYEKGLAY
160 170 180 190 200
KKTSYVNWCP KCETVLANEQ VEDGACWRCD SEVTQKELEQ WFFRITDYAE
210 220 230 240 250
ELLEYTEKLP GWPERVLTMQ RNWIGKSYGC EIDFPVEGSL AKIKVFTTRQ
260 270 280 290 300
DTLYGATFMS LAPEHPMALE LTTPDRRAEV EAFIDKVKKT DKIKRTAEDF
310 320 330 340 350
EKEGVFTGSY CINPVTNRRM PVFLANFVLL DYGTGAVMAV PTHDQRDFEF
360 370 380 390 400
ARKYDLPLQV VIQPEGETLD PAAMATAYTE VGTMVNSGTF DGLRSDEAKE
410 420 430 440 450
KIADYLAKEG IGTKTVNFRL RDWGISRQRY WGNPIPVIYC DICGVVPVPE
460 470 480 490 500
KDLPVVLPMD VEFTGEGGSP LKKLDSFVNV PCPQCGQMAR RETDTMDTFV
510 520 530 540 550
QSSWYFLRYC CPDFAAGPID KARAEYWMSV DQYIGGIEHA VLHLLYARFF
560 570 580 590 600
TKALRDLGYV TVDEPFTNLL TQGMVIKDGA KMSKSKGNVV DPDALINRYG
610 620 630 640 650
ADTARLFSLF AAPPEKDLDW SDQGVDGSYR FLSRVWRLVC DLLPFVGKGG
660 670 680 690 700
AVDSASLSDD ARGLRRAVHK TIRKVTDDID ERFHFNTAIA AIMELVNAIY
710 720 730 740 750
AFEPKNAPEN GPVLTEAIES VVIMLSPFVP HVTEELWEAL GHQGGVEAAG
760 770 780 790 800
WPSFDPSAAV DEEFLIVVQV NGKLRGKVTV ATDATEEQVK AAAFADEKVK
810 820
PWIEGKQLRK AIYVPGKLLN IVVG
Length:824
Mass (Da):93,514
Last modified:November 22, 2005 - v1
Checksum:i63EB85F98765DD2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB32525.1.
RefSeqiWP_004514498.1. NC_007517.1.
YP_006721261.1. NC_007517.1.

Genome annotation databases

EnsemblBacteriaiABB32525; ABB32525; Gmet_2300.
GeneIDi3739328.
KEGGigme:Gmet_2300.
PATRICi22003856. VBIGeoMet55070_2341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB32525.1 .
RefSeqi WP_004514498.1. NC_007517.1.
YP_006721261.1. NC_007517.1.

3D structure databases

ProteinModelPortali Q39T99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269799.Gmet_2300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB32525 ; ABB32525 ; Gmet_2300 .
GeneIDi 3739328.
KEGGi gme:Gmet_2300.
PATRICi 22003856. VBIGeoMet55070_2341.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci GMET269799:GHNY-2339-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Geobacter metallireducens GS-15."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS-15 / ATCC 53774 / DSM 7210.

Entry informationi

Entry nameiSYL_GEOMG
AccessioniPrimary (citable) accession number: Q39T99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3