Q39T72 (KGUA_GEOMG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	Gmet_2327

Organism

Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210) [Complete proteome] [HAMAP]

Taxonomic identifier

269799 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter › Geobacter metallireducens

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000266329
Regions
	Domain	5 – 183	179	Guanylate kinase-like
	Nucleotide binding	12 – 19	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q39T72 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 49821F1711740F98	FASTA	203	23,403
	10 20 30 40 50 60 MKREGVLYII SAPSGAGKTT LCKEIIDIFP HLRHSVSYTT RQPRAGEVHG KDYYFISMDE 70 80 90 100 110 120 FRSMVDKGEF AEWAEVHGNC YGTSIRTLEE CRITGIDLIL DIDIQGARQL KERYEGGVYI 130 140 150 160 170 180 FILPPSYEEL RRRLNGRSSD SDDVISRRID AAAGEIRESR WYDYIIVNDQ FSRAVEELKS 190 200 VVVAERCRTF RVLETVTERF DMG

References

[1]

"Complete sequence of Geobacter metallireducens GS-15." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GS-15 / ATCC 53774 / DSM 7210.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000148 Genomic DNA. Translation: ABB32552.1.
RefSeq	YP_006721288.1. NC_007517.1.
3D structure databases
HSSP	HSSP built from PDB template 2ANC based on UniProtKB P60546.
ProteinModelPortal	Q39T72.
ModBase	Search...
Protein-protein interaction databases
STRING	269799.Gmet_2327.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB32552; ABB32552; Gmet_2327.
GeneID	3739488.
KEGG	gme:Gmet_2327.
PATRIC	22003910. VBIGeoMet55070_2368.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HOG000037638.
KO	K00942.
OMA	EWAEFAG.
ProtClustDB	PRK00300.
Enzyme and pathway databases
BioCyc	GMET269799:GHNY-2364-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_GEOMG

Accession

Primary (citable) accession number: Q39T72

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program