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Q39T49

- LPXB_GEOMG

UniProt

Q39T49 - LPXB_GEOMG

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Gmet_2350
Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciGMET269799:GHNY-2389-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Gmet_2350
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007073: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000255183Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269799.Gmet_2350.

Structurei

3D structure databases

ProteinModelPortaliQ39T49.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39T49-1 [UniParc]FASTAAdd to Basket

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MGTAPNKRVM IVAGEASGDL HGSNLVKEAL RLDPTLSFFG IGGPHMRAAG    50
VETVVDSSEM AVVGLVEVLA HFGVIYKAYA TLKRLITTNP PDLLILIDYP 100
DFNMLVAKVA KRAGVKVLYY ISPQVWAWRT GRVKKIARLV DRMAVVFPFE 150
VPFYEKAGVP VSFVGHPLAD RVSPSMSRSE ALAAFGLDPS RRVVGLFPGS 200
RRGEIARLFP VILESAKLLR DRYPGIQFIL PLASSLTDAD IAPHLAASGL 250
EVVVARDKVY DVMQVCDAIA TVSGTVTLEI ALMGVPMVII YTVSPLTYEV 300
GKRLIRVDHI GICNIVAGER VVPELIQDEA TAERIAAEIG RYLDDPVHTE 350
KTRAGLARVR EKLGSGGCSE RVAGIVLEML GKKR 384
Length:384
Mass (Da):41,622
Last modified:November 22, 2005 - v1
Checksum:iB3E98A1B1011F88C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000148 Genomic DNA. Translation: ABB32575.1.
RefSeqiWP_011366042.1. NC_007517.1.
YP_006721311.1. NC_007517.1.

Genome annotation databases

EnsemblBacteriaiABB32575; ABB32575; Gmet_2350.
GeneIDi3738810.
KEGGigme:Gmet_2350.
PATRICi22003950. VBIGeoMet55070_2388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000148 Genomic DNA. Translation: ABB32575.1 .
RefSeqi WP_011366042.1. NC_007517.1.
YP_006721311.1. NC_007517.1.

3D structure databases

ProteinModelPortali Q39T49.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269799.Gmet_2350.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB32575 ; ABB32575 ; Gmet_2350 .
GeneIDi 3738810.
KEGGi gme:Gmet_2350.
PATRICi 22003950. VBIGeoMet55070_2388.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci GMET269799:GHNY-2389-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Geobacter metallireducens GS-15."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS-15 / ATCC 53774 / DSM 7210.

Entry informationi

Entry nameiLPXB_GEOMG
AccessioniPrimary (citable) accession number: Q39T49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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