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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
Short name:
(3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
Gene namesi
Name:fabZUniRule annotation
Ordered Locus Names:Gmet_2354
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000007073 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002308141 – 1503-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZAdd BLAST150

Interactioni

Protein-protein interaction databases

STRINGi269799.Gmet_2354.

Structurei

3D structure databases

ProteinModelPortaliQ39T45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YXN. Bacteria.
COG0764. LUCA.
HOGENOMiHOG000277829.
KOiK02372.
OMAiAICAKKE.
OrthoDBiPOG091H005Q.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ. 1 hit.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39T45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVFDINEI MKILPHRYPF LLVDRIVEHV PGERIVGIKN VTINEPFFQG
60 70 80 90 100
HFPGHPIMPG VLIVEAMAQV GGILAYMASD DEVRNKVCYF ASIDNVKFRK
110 120 130 140 150
PVLPGDQLRI EVAATGCKRG IWCFSAKAIV KGKVTTQAEL KATFADKDRL
Length:150
Mass (Da):16,769
Last modified:November 22, 2005 - v1
Checksum:i8E1DEC6F8BF3ADA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB32579.1.
RefSeqiWP_004513266.1. NC_007517.1.

Genome annotation databases

EnsemblBacteriaiABB32579; ABB32579; Gmet_2354.
KEGGigme:Gmet_2354.
PATRICi22003958. VBIGeoMet55070_2392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB32579.1.
RefSeqiWP_004513266.1. NC_007517.1.

3D structure databases

ProteinModelPortaliQ39T45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269799.Gmet_2354.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB32579; ABB32579; Gmet_2354.
KEGGigme:Gmet_2354.
PATRICi22003958. VBIGeoMet55070_2392.

Phylogenomic databases

eggNOGiENOG4108YXN. Bacteria.
COG0764. LUCA.
HOGENOMiHOG000277829.
KOiK02372.
OMAiAICAKKE.
OrthoDBiPOG091H005Q.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ. 1 hit.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFABZ_GEOMG
AccessioniPrimary (citable) accession number: Q39T45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.