Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2-dehydropantoate 2-reductase

Gene

panE

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.UniRule annotation

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
  2. 2-dehydropantoate 2-reductase (panE)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Pantothenate biosynthesisUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydropantoate 2-reductaseUniRule annotation (EC:1.1.1.169UniRule annotation)
Alternative name(s):
Ketopantoate reductaseUniRule annotation
Gene namesi
Name:panEImported
Ordered Locus Names:Gmet_2643Imported
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)Imported
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000007073 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi269799.Gmet_2643.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HN2X-ray2.50A/B/C/D2-302[»]
ProteinModelPortaliQ39SB2.
SMRiQ39SB2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ39SB2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 149ApbAInterPro annotationAdd BLAST147
Domaini176 – 299ApbA_CInterPro annotationAdd BLAST124

Sequence similaritiesi

Belongs to the ketopantoate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41084M5. Bacteria.
COG1893. LUCA.
HOGENOMiHOG000050222.
KOiK00077.
OMAiKLVWNIP.
OrthoDBiPOG091H01MS.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR003710. ApbA.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39SB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAIVGAGA LGLYYGALLQ RSGEDVHFLL RRDYEAIAGN GLKVFSINGD
60 70 80 90 100
FTLPHVKGYR APEEIGPMDL VLVGLKTFAN SRYEELIRPL VEEGTQILTL
110 120 130 140 150
QNGLGNEEAL ATLFGAERII GGVAFLCSNR GEPGEVHHLG AGRIILGEFL
160 170 180 190 200
PRDTGRIEEL AAMFRQAGVD CRTTDDLKRA RWEKLVWNIP FNGLCALLQQ
210 220 230 240 250
PVNLILARDV SRKLVRGIML EVIAGANAQG LATFIADGYV DDMLEFTDAM
260 270 280 290 300
GEYKPSMEID REEGRPLEIA AIFRTPLAYG AREGIAMPRV EMLATLLEQA

TG
Length:302
Mass (Da):33,101
Last modified:November 22, 2005 - v1
Checksum:iE2E91015CFFA1B29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB32862.1.
RefSeqiWP_004511818.1. NC_007517.1.

Genome annotation databases

EnsemblBacteriaiABB32862; ABB32862; Gmet_2643.
KEGGigme:Gmet_2643.
PATRICi22004534. VBIGeoMet55070_2680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB32862.1.
RefSeqiWP_004511818.1. NC_007517.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HN2X-ray2.50A/B/C/D2-302[»]
ProteinModelPortaliQ39SB2.
SMRiQ39SB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269799.Gmet_2643.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB32862; ABB32862; Gmet_2643.
KEGGigme:Gmet_2643.
PATRICi22004534. VBIGeoMet55070_2680.

Phylogenomic databases

eggNOGiENOG41084M5. Bacteria.
COG1893. LUCA.
HOGENOMiHOG000050222.
KOiK00077.
OMAiKLVWNIP.
OrthoDBiPOG091H01MS.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Miscellaneous databases

EvolutionaryTraceiQ39SB2.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR003710. ApbA.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ39SB2_GEOMG
AccessioniPrimary (citable) accession number: Q39SB2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.