Q39RT4 (DXS2_GEOMG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase 2
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 2
Short name=DXP synthase 2
Short name=DXPS 2

Gene names

Name:	dxs2
Ordered Locus Names:	Gmet_2822

Organism

Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210) [Complete proteome] [HAMAP]

Taxonomic identifier

269799 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 635	635	1-deoxy-D-xylulose-5-phosphate synthase 2 HAMAP MF_00315		PRO_0000256423

Sequences

	Sequence		Length	Mass (Da)
	Q39RT4 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 90544F82FD31FB30	FASTA	635	67,995
	10 20 30 40 50 60 MYKLLDTITG PADLKNIPRE ELPGLADEIR RFLIETVSQT GGHLASNLGA VELSVALHYC 70 80 90 100 110 120 FDSPADKLIW DVGHQAYTHK ILTGRRESFH TQRQYKGISG FPKRSESPHD AFGAGHSSTS 130 140 150 160 170 180 ISAGLGMAAA QDLKGSGSRA IAVIGDGSLT GGMAYEALNQ AGHLKKNLIV VLNDNEMSIS 190 200 210 220 230 240 QNVGAFSSFV SRKMTGSDFR KLKKEMQGLL ENIPAIGKDI LHFARRAENS LKGFLTPGML 250 260 270 280 290 300 FEALGFDYIG PIPGHDLPQL LEVFENVKGL EGPVLVHVMT TKGKGYQPAE ENPAAFHGVG 310 320 330 340 350 360 PFDVATGKTT GGKPGAASYT GVFGATLVKL AEEDEKIIAI TAAMPDGTGL TPFAKRFPER 370 380 390 400 410 420 FFDVGIAEQH ALTFAAGLAA DGFRPVTAIY STFLQRAYDQ VFHDVCLQKL PVTMALDRGG 430 440 450 460 470 480 LVGDDGPTHH GTFDLSYLRH LPEMTLMAPK DENELQHMLK TAIYAGRPVA LRYPRGAGYG 490 500 510 520 530 540 LPLDQTIQSL EIGRGELLTE GDDVAIVAIG STVYPAQEAA KLLEARGIRA TVVNARFVKP 550 560 570 580 590 600 LDRELILGAA RRTGCIVTVE ENALQGGFGS AVLELLADEG MTDVRAKRIG IPDRFIEQGP 610 620 630 QPQLRKDLGL DGAGIAATVE AFLTAKGQAA LSLVK

References

[1]

"Complete sequence of Geobacter metallireducens GS-15." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GS-15 / ATCC 53774 / DSM 7210.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000148 Genomic DNA. Translation: ABB33040.1.
RefSeq	YP_385765.1. NC_007517.1.
3D structure databases
ProteinModelPortal	Q39RT4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q39RT4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3741088.
GenomeReviews	Gene locus Gmet_2822 in contig CP000148_GR.
KEGG	gme:Gmet_2822.
NMPDR	fig|269799.3.peg.2800.
PATRIC	22004886. VBIGeoMet55070_2856.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	QYDISYM.
PhylomeDB	Q39RT4.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	GMET269799:GMET_2822-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR001017. DH_E1. IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS2_GEOMG

Accession

Primary (citable) accession number: Q39RT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program