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Q39R36

- GCH4_GEOMG

UniProt

Q39R36 - GCH4_GEOMG

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei147 – 1471May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciGMET269799:GHNY-3120-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Gmet_3074
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007073: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261GTP cyclohydrolase FolE2PRO_0000289491Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269799.Gmet_3074.

Structurei

3D structure databases

ProteinModelPortaliQ39R36.
SMRiQ39R36. Positions 15-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39R36-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTMPDMQKT SDTRKIPINK VGVKDISYPI VVMDKNKKFQ QTVARINMYV
60 70 80 90 100
DLPHHFKGTH MSRFVEILNA YREDIALDKM EPILQKMKEK LGASSAHLEI
110 120 130 140 150
EFPYFIEKRA PVSGARSLME YTCTFCGSLG EEFDFVLGVQ IPVTSLCPCS
160 170 180 190 200
KELSRYGAHN QRSHITVRLR YTDFIWIEDL VAMIEECGSS PVWSLLKRVD
210 220 230 240 250
EQYVTERAYE NPKFVEDIVR EVTQKLLAHD AITWFSVEAE NFESIHKHSA
260
YAAIERDKKM T
Length:261
Mass (Da):30,182
Last modified:November 22, 2005 - v1
Checksum:i080D014BD50FF10F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB33288.1.
RefSeqiYP_006722024.1. NC_007517.1.

Genome annotation databases

EnsemblBacteriaiABB33288; ABB33288; Gmet_3074.
GeneIDi3740772.
KEGGigme:Gmet_3074.
PATRICi22005398. VBIGeoMet55070_3105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000148 Genomic DNA. Translation: ABB33288.1 .
RefSeqi YP_006722024.1. NC_007517.1.

3D structure databases

ProteinModelPortali Q39R36.
SMRi Q39R36. Positions 15-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269799.Gmet_3074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB33288 ; ABB33288 ; Gmet_3074 .
GeneIDi 3740772.
KEGGi gme:Gmet_3074.
PATRICi 22005398. VBIGeoMet55070_3105.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci GMET269799:GHNY-3120-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Geobacter metallireducens GS-15."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS-15 / ATCC 53774 / DSM 7210.

Entry informationi

Entry nameiGCH4_GEOMG
AccessioniPrimary (citable) accession number: Q39R36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3