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Q39QX7

- UPPP_GEOMG

UniProt

Q39QX7 - UPPP_GEOMG

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciGMET269799:GHNY-3179-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Gmet_3133
OrganismiGeobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Taxonomic identifieri269799 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007073: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Undecaprenyl-diphosphatasePRO_0000227619Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269799.Gmet_3133.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 5920HelicalUniRule annotationAdd
BLAST
Transmembranei87 – 10721HelicalUniRule annotationAdd
BLAST
Transmembranei116 – 13621HelicalUniRule annotationAdd
BLAST
Transmembranei160 – 18021HelicalUniRule annotationAdd
BLAST
Transmembranei188 – 20821HelicalUniRule annotationAdd
BLAST
Transmembranei220 – 24021HelicalUniRule annotationAdd
BLAST
Transmembranei247 – 26721HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiIEGPFRD.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39QX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPLHATVLG AIQGLTEVLP VSSSAHLILI PWLFGWPESG ITFDVALHLG
60 70 80 90 100
TLIALALYFR RDIAELVVNA LSGLTGGAHS SATRLPWYII AGCVPAAIVG
110 120 130 140 150
KTLEEPIEAI FRANPAIIAA FLIGFGLLLA LADTLGSKKS RMDQIDLKNA
160 170 180 190 200
MMIGLAQCLA LLPGVSRSGI TITAALFLGF SRETAARFSF LLSLPIVAGA
210 220 230 240 250
ALLKVGHLVR HGVPEGELQP LLIGVGVSAV FGYVSVALLL KLVQRYSLYP
260
FVWYRLLAGA GVLLFIFNQ
Length:269
Mass (Da):28,565
Last modified:November 22, 2005 - v1
Checksum:i747E26482FF33783
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000148 Genomic DNA. Translation: ABB33347.1.
RefSeqiWP_004514308.1. NC_007517.1.
YP_006722084.1. NC_007517.1.

Genome annotation databases

EnsemblBacteriaiABB33347; ABB33347; Gmet_3133.
GeneIDi3740907.
KEGGigme:Gmet_3133.
PATRICi22005520. VBIGeoMet55070_3166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000148 Genomic DNA. Translation: ABB33347.1 .
RefSeqi WP_004514308.1. NC_007517.1.
YP_006722084.1. NC_007517.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269799.Gmet_3133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB33347 ; ABB33347 ; Gmet_3133 .
GeneIDi 3740907.
KEGGi gme:Gmet_3133.
PATRICi 22005520. VBIGeoMet55070_3166.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi IEGPFRD.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci GMET269799:GHNY-3179-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Geobacter metallireducens GS-15."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS-15 / ATCC 53774 / DSM 7210.

Entry informationi

Entry nameiUPPP_GEOMG
AccessioniPrimary (citable) accession number: Q39QX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3