UniProtKB - Q39PA6 (TYPH_BURL3)
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Protein
Thymidine phosphorylase
Gene
deoA
Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Functioni
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation
Catalytic activityi
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
: dTMP biosynthesis via salvage pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.UniRule annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Thymidine phosphorylase (deoA), Thymidine phosphorylase (deoA), Thymidine phosphorylase (deoA)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.
GO - Molecular functioni
- phosphorylase activity Source: InterPro
- pyrimidine-nucleoside phosphorylase activity Source: InterPro
- thymidine phosphorylase activity Source: UniProtKB-EC
GO - Biological processi
- pyrimidine nucleobase metabolic process Source: InterPro
- pyrimidine nucleoside metabolic process Source: InterPro
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00578; UER00638. |
Names & Taxonomyi
Protein namesi | Recommended name: Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)Alternative name(s): TdRPaseUniRule annotation |
Gene namesi | Name:deoAUniRule annotation Ordered Locus Names:Bcep18194_C6660 |
Organismi | Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) |
Taxonomic identifieri | 482957 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000335773 | 1 – 438 | Thymidine phosphorylaseAdd BLAST | 438 |
Interactioni
Subunit structurei
Homodimer.UniRule annotation
Structurei
3D structure databases
ProteinModelPortali | Q39PA6. |
SMRi | Q39PA6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000047313. |
KOi | K00758. |
OMAi | VHSIGGV. |
OrthoDBi | POG091H02BC. |
Family and domain databases
Gene3Di | 3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit. |
HAMAPi | MF_01628. Thymid_phosp. 1 hit. |
InterProi | View protein in InterPro IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR036320. Glycosyl_Trfase_fam3_N_dom)sf. IPR035902. Nuc_phospho_transferase. IPR036566. PYNP-like_C_sf. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR017872. Pyrmidine_PPase_CS. IPR000053. Thymidine/pyrmidine_PPase. IPR013465. Thymidine_Pase. |
PANTHERi | PTHR10515. PTHR10515. 1 hit. |
Pfami | View protein in Pfam PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. |
PIRSFi | PIRSF000478. TP_PyNP. 1 hit. |
SMARTi | View protein in SMART SM00941. PYNP_C. 1 hit. |
SUPFAMi | SSF47648. SSF47648. 1 hit. SSF52418. SSF52418. 1 hit. SSF54680. SSF54680. 1 hit. |
TIGRFAMsi | TIGR02643. T_phosphoryl. 1 hit. TIGR02644. Y_phosphoryl. 1 hit. |
PROSITEi | View protein in PROSITE PS00647. THYMID_PHOSPHORYLASE. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q39PA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLPQEFIRQ KRNRQALDRD GIAAFVRGVT DGSVTEGQVA AFAMAVYFND
60 70 80 90 100
LSTDERVALT LAQRDSGDVL DWHALELDGP VIDKHSTGGV GDVVSLMLGP
110 120 130 140 150
MVAACGGYVP MISGRGLGHT GGTLDKLSAI PGYNVTPDTD AFRRAVRDVG
160 170 180 190 200
VAIIGQTARL APADMRIYAI RDVTATVESV AMITASILSK KLAAGLDGLV
210 220 230 240 250
MDVKVGSGAF MPTAEQSAEL ARSIVDVGNG AGMKTTAILT DMNQSLAPCA
260 270 280 290 300
GNALEVACAI DYLTGKSRPA RLHDVTMALS AELLVTGGLA HDVADARAKL
310 320 330 340 350
LRALDSGAAA ERFARMVTAL GGPADLIDAP ARHLARAKVV VPVPARASGV
360 370 380 390 400
VQRVDCRALG LAVVALGGGR TRAADAIDYS VGLTALAEIG QRVEADQPLG
410 420 430
YVHARDAAAA AHAVDTIQRS YVLGEAGDAP PTIYQQIG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000150 Genomic DNA. Translation: ABB05710.1. |
RefSeqi | WP_011349354.1. NC_007509.1. |
Genome annotation databases
EnsemblBacteriai | ABB05710; ABB05710; Bcep18194_C6660. |
KEGGi | bur:Bcep18194_C6660. |
PATRICi | fig|482957.22.peg.7170. |
Similar proteinsi
Entry informationi
Entry namei | TYPH_BURL3 | |
Accessioni | Q39PA6Primary (citable) accession number: Q39PA6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | November 22, 2005 | |
Last modified: | March 28, 2018 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |