deoA

Functionⁱ

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityⁱ

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Enzyme and pathway databases

BioCycⁱ	BSP269483:GHLS-6744-MONOMER.
UniPathwayⁱ	UPA00578; UER00638.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thymidine phosphorylaseUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_01628 (EC:2.4.2.4UniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_01628 ) Alternative name(s): TdRPaseUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_01628
Gene namesⁱ	Name:deoAUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_01628 Ordered Locus Names:Bcep18194_C6660
Organismⁱ	Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifierⁱ	482957 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex
Proteomesⁱ	UP000002705: Chromosome 3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 438	438	Thymidine phosphorylase		PRO_0000335773	Add BLAST

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	269483.Bcep18194_C6660.

STRINGⁱ

269483.Bcep18194_C6660.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q39PA6.
SMRⁱ	Q39PA6. Positions 1-437.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	COG0213.
HOGENOMⁱ	HOG000047313.
KOⁱ	K00758.
OMAⁱ	CGLAVPM.
OrthoDBⁱ	EOG61ZTGG.

Family and domain databases

Gene3Dⁱ	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAPⁱ	MF_01628. Thymid_phosp.
InterProⁱ	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013465. Thymidine_Pase. [Graphical view]
PANTHERⁱ	PTHR10515. PTHR10515. 1 hit.
Pfamⁱ	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSFⁱ	PIRSF000478. TP_PyNP. 1 hit.
SMARTⁱ	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAMⁱ	SSF47648. SSF47648. 1 hit. SSF52418. SSF52418. 1 hit. SSF54680. SSF54680. 1 hit.
TIGRFAMsⁱ	TIGR02643. T_phosphoryl. 1 hit. TIGR02644. Y_phosphoryl. 1 hit.
PROSITEⁱ	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Q39PA6-1 [UniParc]FASTA Add to Basket

« Hide

        10         20         30         40         50
MFLPQEFIRQ KRNRQALDRD GIAAFVRGVT DGSVTEGQVA AFAMAVYFND 
        60         70         80         90        100
LSTDERVALT LAQRDSGDVL DWHALELDGP VIDKHSTGGV GDVVSLMLGP 
       110        120        130        140        150
MVAACGGYVP MISGRGLGHT GGTLDKLSAI PGYNVTPDTD AFRRAVRDVG 
       160        170        180        190        200
VAIIGQTARL APADMRIYAI RDVTATVESV AMITASILSK KLAAGLDGLV 
       210        220        230        240        250
MDVKVGSGAF MPTAEQSAEL ARSIVDVGNG AGMKTTAILT DMNQSLAPCA 
       260        270        280        290        300
GNALEVACAI DYLTGKSRPA RLHDVTMALS AELLVTGGLA HDVADARAKL 
       310        320        330        340        350
LRALDSGAAA ERFARMVTAL GGPADLIDAP ARHLARAKVV VPVPARASGV 
       360        370        380        390        400
VQRVDCRALG LAVVALGGGR TRAADAIDYS VGLTALAEIG QRVEADQPLG 
       410        420        430 
YVHARDAAAA AHAVDTIQRS YVLGEAGDAP PTIYQQIG

Length:438

Mass (Da):45,386

Last modified:November 22, 2005 - v1

Checksum:ⁱCA727A09A2AE9F26

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000150 Genomic DNA. Translation: ABB05710.1.
RefSeqⁱ	WP_011349354.1. NC_007509.1. YP_366354.1. NC_007509.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABB05710; ABB05710; Bcep18194_C6660.
GeneIDⁱ	3733982.
KEGGⁱ	bur:Bcep18194_C6660.
PATRICⁱ	19281340. VBIBurSp120713_0129.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000150 Genomic DNA. Translation: ABB05710.1 .
RefSeqⁱ	WP_011349354.1. NC_007509.1. YP_366354.1. NC_007509.1.

3D structure databases

ProteinModelPortalⁱ	Q39PA6.
SMRⁱ	Q39PA6. Positions 1-437.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	269483.Bcep18194_C6660.

STRINGⁱ

269483.Bcep18194_C6660.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABB05710 ; ABB05710 ; Bcep18194_C6660 .
GeneIDⁱ	3733982.
KEGGⁱ	bur:Bcep18194_C6660.
PATRICⁱ	19281340. VBIBurSp120713_0129.

Phylogenomic databases

eggNOGⁱ	COG0213.
HOGENOMⁱ	HOG000047313.
KOⁱ	K00758.
OMAⁱ	CGLAVPM.
OrthoDBⁱ	EOG61ZTGG.

Enzyme and pathway databases

UniPathwayⁱ	UPA00578 ; UER00638 .
BioCycⁱ	BSP269483:GHLS-6744-MONOMER.

Family and domain databases

Gene3Dⁱ	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAPⁱ	MF_01628. Thymid_phosp.
InterProⁱ	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013465. Thymidine_Pase. [Graphical view ]
PANTHERⁱ	PTHR10515. PTHR10515. 1 hit.
Pfamⁱ	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view ]
PIRSFⁱ	PIRSF000478. TP_PyNP. 1 hit.
SMARTⁱ	SM00941. PYNP_C. 1 hit. [Graphical view ]
SUPFAMⁱ	SSF47648. SSF47648. 1 hit. SSF52418. SSF52418. 1 hit. SSF54680. SSF54680. 1 hit.
TIGRFAMsⁱ	TIGR02643. T_phosphoryl. 1 hit. TIGR02644. Y_phosphoryl. 1 hit.
PROSITEⁱ	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view ]
ProtoNetⁱ	Search...

Publicationsⁱ

"Complete sequence of chromosome 3 of Burkholderia sp. 383."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383.

Entry informationⁱ

Entry nameⁱ

TYPH_BURL3

Accessionⁱ

Primary (citable) accession number: Q39PA6

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 22, 2005
Last modified:	January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

External Data

Dasty 3

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

Proteomes

UniRef

Supporting data

UniParc

Help

Q39PA6

- TYPH_BURL3

UniProt

Q39PA6 - TYPH_BURL3

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Thymidine phosphorylase

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<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

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Molecule processing

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Protein-protein interaction databases

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3D structure databases

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<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Family and domain databases

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Sequence databases

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Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

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Functionⁱ

Pathwayⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Publicationsⁱ

Entry informationⁱ

Miscellaneousⁱ