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Q39PA6

- TYPH_BURS3

UniProt

Q39PA6 - TYPH_BURS3

Protein

Thymidine phosphorylase

Gene

deoA

Organism
Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciBSP269483:GHLS-6744-MONOMER.
    UniPathwayiUPA00578; UER00638.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
    Alternative name(s):
    TdRPaseUniRule annotation
    Gene namesi
    Name:deoAUniRule annotation
    Ordered Locus Names:Bcep18194_C6660
    OrganismiBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
    Taxonomic identifieri482957 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002705: Chromosome 3

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Thymidine phosphorylasePRO_0000335773Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi269483.Bcep18194_C6660.

    Structurei

    3D structure databases

    ProteinModelPortaliQ39PA6.
    SMRiQ39PA6. Positions 1-437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000047313.
    KOiK00758.
    OMAiHYRITED.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_01628. Thymid_phosp.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013465. Thymidine_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
    TIGR02644. Y_phosphoryl. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q39PA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLPQEFIRQ KRNRQALDRD GIAAFVRGVT DGSVTEGQVA AFAMAVYFND    50
    LSTDERVALT LAQRDSGDVL DWHALELDGP VIDKHSTGGV GDVVSLMLGP 100
    MVAACGGYVP MISGRGLGHT GGTLDKLSAI PGYNVTPDTD AFRRAVRDVG 150
    VAIIGQTARL APADMRIYAI RDVTATVESV AMITASILSK KLAAGLDGLV 200
    MDVKVGSGAF MPTAEQSAEL ARSIVDVGNG AGMKTTAILT DMNQSLAPCA 250
    GNALEVACAI DYLTGKSRPA RLHDVTMALS AELLVTGGLA HDVADARAKL 300
    LRALDSGAAA ERFARMVTAL GGPADLIDAP ARHLARAKVV VPVPARASGV 350
    VQRVDCRALG LAVVALGGGR TRAADAIDYS VGLTALAEIG QRVEADQPLG 400
    YVHARDAAAA AHAVDTIQRS YVLGEAGDAP PTIYQQIG 438
    Length:438
    Mass (Da):45,386
    Last modified:November 22, 2005 - v1
    Checksum:iCA727A09A2AE9F26
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000150 Genomic DNA. Translation: ABB05710.1.
    RefSeqiWP_011349354.1. NC_007509.1.
    YP_366354.1. NC_007509.1.

    Genome annotation databases

    EnsemblBacteriaiABB05710; ABB05710; Bcep18194_C6660.
    GeneIDi3733982.
    KEGGibur:Bcep18194_C6660.
    PATRICi19281340. VBIBurSp120713_0129.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000150 Genomic DNA. Translation: ABB05710.1 .
    RefSeqi WP_011349354.1. NC_007509.1.
    YP_366354.1. NC_007509.1.

    3D structure databases

    ProteinModelPortali Q39PA6.
    SMRi Q39PA6. Positions 1-437.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269483.Bcep18194_C6660.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB05710 ; ABB05710 ; Bcep18194_C6660 .
    GeneIDi 3733982.
    KEGGi bur:Bcep18194_C6660.
    PATRICi 19281340. VBIBurSp120713_0129.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000047313.
    KOi K00758.
    OMAi HYRITED.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    UniPathwayi UPA00578 ; UER00638 .
    BioCyci BSP269483:GHLS-6744-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_01628. Thymid_phosp.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013465. Thymidine_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02643. T_phosphoryl. 1 hit.
    TIGR02644. Y_phosphoryl. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 3 of Burkholderia sp. 383."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 383.

    Entry informationi

    Entry nameiTYPH_BURS3
    AccessioniPrimary (citable) accession number: Q39PA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3