Q39PA6 (TYPH_BURS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Name:	deoA
Ordered Locus Names:	Bcep18194_C6660

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628
Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628
Pathway	Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro thymidine metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro pyrimidine-nucleoside phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Thymidine phosphorylase HAMAP-Rule MF_01628		PRO_0000335773

Sequences

	Sequence		Length	Mass (Da)
	Q39PA6 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: CA727A09A2AE9F26	FASTA	438	45,386
	10 20 30 40 50 60 MFLPQEFIRQ KRNRQALDRD GIAAFVRGVT DGSVTEGQVA AFAMAVYFND LSTDERVALT 70 80 90 100 110 120 LAQRDSGDVL DWHALELDGP VIDKHSTGGV GDVVSLMLGP MVAACGGYVP MISGRGLGHT 130 140 150 160 170 180 GGTLDKLSAI PGYNVTPDTD AFRRAVRDVG VAIIGQTARL APADMRIYAI RDVTATVESV 190 200 210 220 230 240 AMITASILSK KLAAGLDGLV MDVKVGSGAF MPTAEQSAEL ARSIVDVGNG AGMKTTAILT 250 260 270 280 290 300 DMNQSLAPCA GNALEVACAI DYLTGKSRPA RLHDVTMALS AELLVTGGLA HDVADARAKL 310 320 330 340 350 360 LRALDSGAAA ERFARMVTAL GGPADLIDAP ARHLARAKVV VPVPARASGV VQRVDCRALG 370 380 390 400 410 420 LAVVALGGGR TRAADAIDYS VGLTALAEIG QRVEADQPLG YVHARDAAAA AHAVDTIQRS 430 YVLGEAGDAP PTIYQQIG

References

[1]

"Complete sequence of chromosome 3 of Burkholderia sp. 383." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 383.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000150 Genomic DNA. Translation: ABB05710.1.
RefSeq	YP_366354.1. NC_007509.1.
3D structure databases
ProteinModelPortal	Q39PA6.
SMR	Q39PA6. Positions 1-437.
ModBase	Search...
Protein-protein interaction databases
STRING	269483.Bcep18194_C6660.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB05710; ABB05710; Bcep18194_C6660.
GeneID	3733982.
KEGG	bur:Bcep18194_C6660.
PATRIC	19281340. VBIBurSp120713_0129.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000047313.
KO	K00758.
OMA	LMAIYFR.
ProtClustDB	PRK05820.
Enzyme and pathway databases
BioCyc	BSP269483:GHLS-6744-MONOMER.
UniPathway	UPA00578; UER00638.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_01628. Thymid_phosp.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013465. Thymidine_Pase. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02643. T_phosphoryl. 1 hit. TIGR02644. Y_phosphoryl. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_BURS3

Accession

Primary (citable) accession number: Q39PA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program