deoA

Functionⁱ

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityⁱ

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayⁱ: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Thymidine phosphorylase (deoA), Thymidine phosphorylase (deoA), Thymidine phosphorylase (deoA), Thymidine phosphorylase (deoA)
no protein annotated in this organism

This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functionⁱ

phosphorylase activity Source: InterPro
pyrimidine-nucleoside phosphorylase activity Source: InterPro
thymidine phosphorylase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

pyrimidine nucleobase metabolic process Source: InterPro
pyrimidine nucleoside metabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase

Molecular function

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayⁱ	UPA00578; UER00638.

UniPathwayⁱ

UPA00578; UER00638.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation) Alternative name(s): TdRPaseUniRule annotation
Gene namesⁱ	Name:deoAUniRule annotation Ordered Locus Names:Bcep18194_C6660
Organismⁱ	Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifierⁱ	482957 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex
Proteomesⁱ	UP000002705 Componentⁱ: Chromosome 3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000335773	1 – 438	Thymidine phosphorylaseAdd BLAST		438

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q39PA6.
SMRⁱ	Q39PA6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000047313.
KEGG Orthology (KO) More...KOⁱ	K00758.
OMAⁱ	VHSIGGV.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H02BC.

Family and domain databases

Gene3Dⁱ	3.40.1030.10. 1 hit.
HAMAPⁱ	MF_01628. Thymid_phosp. 1 hit.
InterProⁱ	View protein in InterPro IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR017872. Pyrmidine_PPase_CS. IPR000053. Thymidine/pyrmidine_PPase. IPR013465. Thymidine_Pase.
PANTHERⁱ	PTHR10515. PTHR10515. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit.
PIRSFⁱ	PIRSF000478. TP_PyNP. 1 hit.
SMARTⁱ	View protein in SMART SM00941. PYNP_C. 1 hit.
SUPFAMⁱ	SSF47648. SSF47648. 1 hit. SSF52418. SSF52418. 1 hit. SSF54680. SSF54680. 1 hit.
TIGRFAMsⁱ	TIGR02643. T_phosphoryl. 1 hit. TIGR02644. Y_phosphoryl. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00647. THYMID_PHOSPHORYLASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q39PA6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFLPQEFIRQ KRNRQALDRD GIAAFVRGVT DGSVTEGQVA AFAMAVYFND 
        60         70         80         90        100
LSTDERVALT LAQRDSGDVL DWHALELDGP VIDKHSTGGV GDVVSLMLGP 
       110        120        130        140        150
MVAACGGYVP MISGRGLGHT GGTLDKLSAI PGYNVTPDTD AFRRAVRDVG 
       160        170        180        190        200
VAIIGQTARL APADMRIYAI RDVTATVESV AMITASILSK KLAAGLDGLV 
       210        220        230        240        250
MDVKVGSGAF MPTAEQSAEL ARSIVDVGNG AGMKTTAILT DMNQSLAPCA 
       260        270        280        290        300
GNALEVACAI DYLTGKSRPA RLHDVTMALS AELLVTGGLA HDVADARAKL 
       310        320        330        340        350
LRALDSGAAA ERFARMVTAL GGPADLIDAP ARHLARAKVV VPVPARASGV 
       360        370        380        390        400
VQRVDCRALG LAVVALGGGR TRAADAIDYS VGLTALAEIG QRVEADQPLG 
       410        420        430 
YVHARDAAAA AHAVDTIQRS YVLGEAGDAP PTIYQQIG

Length:438

Mass (Da):45,386

Last modified:November 22, 2005 - v1

Checksum:ⁱCA727A09A2AE9F26

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000150 Genomic DNA. Translation: ABB05710.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011349354.1. NC_007509.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABB05710; ABB05710; Bcep18194_C6660.
KEGGⁱ	bur:Bcep18194_C6660.
PATRICⁱ	fig\|482957.22.peg.7170.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000150 Genomic DNA. Translation: ABB05710.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011349354.1. NC_007509.1.

3D structure databases

ProteinModelPortalⁱ	Q39PA6.
SMRⁱ	Q39PA6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABB05710; ABB05710; Bcep18194_C6660.
KEGGⁱ	bur:Bcep18194_C6660.
PATRICⁱ	fig\|482957.22.peg.7170.

Phylogenomic databases

HOGENOMⁱ	HOG000047313.
KEGG Orthology (KO) More...KOⁱ	K00758.
OMAⁱ	VHSIGGV.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H02BC.

Enzyme and pathway databases

UniPathwayⁱ	UPA00578; UER00638.

UniPathwayⁱ

UPA00578; UER00638.

Family and domain databases

Gene3Dⁱ	3.40.1030.10. 1 hit.
HAMAPⁱ	MF_01628. Thymid_phosp. 1 hit.
InterProⁱ	View protein in InterPro IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR017872. Pyrmidine_PPase_CS. IPR000053. Thymidine/pyrmidine_PPase. IPR013465. Thymidine_Pase.
PANTHERⁱ	PTHR10515. PTHR10515. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit.
PIRSFⁱ	PIRSF000478. TP_PyNP. 1 hit.
SMARTⁱ	View protein in SMART SM00941. PYNP_C. 1 hit.
SUPFAMⁱ	SSF47648. SSF47648. 1 hit. SSF52418. SSF52418. 1 hit. SSF54680. SSF54680. 1 hit.
TIGRFAMsⁱ	TIGR02643. T_phosphoryl. 1 hit. TIGR02644. Y_phosphoryl. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00647. THYMID_PHOSPHORYLASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TYPH_BURL3
Accessionⁱ	Q39PA6Primary (citable) accession number: Q39PA6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
	Last sequence update:	November 22, 2005
	Last modified:	June 7, 2017
	This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - Q39PA6 (TYPH_BURL3)

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Thymidine phosphorylase

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: dTMP biosynthesis via salvage pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q39PA6 (TYPH_BURL3)

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Thymidine phosphorylase

deoA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: dTMP biosynthesis via salvage pathway

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: dTMP biosynthesis via salvage pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ