ID   Q39P46_BURL3            Unreviewed;       564 AA.
AC   Q39P46;
DT   22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2005, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=Acetolactate synthase, large subunit {ECO:0000313|EMBL:ABB05770.1};
DE            EC=2.2.1.6 {ECO:0000313|EMBL:ABB05770.1};
GN   OrderedLocusNames=Bcep18194_C6721 {ECO:0000313|EMBL:ABB05770.1};
OS   Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 /
OS   R18194 / 383).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=482957 {ECO:0000313|EMBL:ABB05770.1, ECO:0000313|Proteomes:UP000002705};
RN   [1] {ECO:0000313|Proteomes:UP000002705}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383
RC   {ECO:0000313|Proteomes:UP000002705};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 3 of Burkholderia sp. 383.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP000150; ABB05770.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q39P46; -.
DR   KEGG; bur:Bcep18194_C6721; -.
DR   PATRIC; fig|482957.22.peg.7238; -.
DR   HOGENOM; CLU_013748_3_1_4; -.
DR   Proteomes; UP000002705; Chromosome 3.
DR   GO; GO:0003984; F:acetolactate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd00568; TPP_enzymes; 1.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR18968:SF167; 2-KETOARGININE DECARBOXYLASE ARUI-RELATED; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132};
KW   Transferase {ECO:0000313|EMBL:ABB05770.1}.
FT   DOMAIN          27..137
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          216..348
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          419..553
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   564 AA;  58456 MW;  E97B79E1BBDE9F7D CRC64;
     MNHPATVSSI AGARKATAAP CHARPRTCGE ALVDLLERHG VECVFGIPGV HTVELYRGLA
     ASSIRHVTPR HEQGAGFMAD GYARVTGRPG VCFIITGPGM TNIATAMAQA YADSIPMLVI
     SSVNARRELG SGDGRLHELP SQRDVFAGLT AFSHTLLDAA DLPQVLARAF AVFASARPRP
     VHIEIPLDVI VMPAPALSDA PPALPARPAP DANALAAAAD LLAHARRPLI LAGGGAIHAA
     AELRELAERL HAPVALTINA KGLLPAGHPL LIGSTQSLPA TRAAIRDADV VLAVGTELGE
     TDYDVTFDGG FAIDGRLIRI DIDAQQLMRN ARAEIAIAGD SQLALGALST RLHETPAPTP
     DAGWGAPRVA AVRAAIAATH DSAAQSQALL IDTIVATLPG AIIAGDSTSP VYVGNFTHDA
     PAPRSWFNSS TGYGTLGYGL PAAIGAKLAA PARPVVCLIG DGGLQFTLPE LASAVEARLP
     VIVIVWNNHG YGEIRKYMVA RDITPVGVDP YTPDFQVLAR GFGCAAHTAA TPGALAAALR
     DAAARAIPTV IEIDEATWFG QVQR
//