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Protein
Submitted name:

Acetolactate synthase, large subunit

Gene

Bcep18194_C6721

Organism
Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. acetolactate synthase activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Keywords - Ligandi

Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

BioCyciBSP269483:GHLS-6805-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Acetolactate synthase, large subunitImported (EC:2.2.1.6Imported)
Gene namesi
Ordered Locus Names:Bcep18194_C6721Imported
OrganismiBurkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)Imported
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002705: Chromosome 3

Interactioni

Protein-protein interaction databases

STRINGi269483.Bcep18194_C6721.

Structurei

3D structure databases

ProteinModelPortaliQ39P46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TPP enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0028.
HOGENOMiHOG000258446.
KOiK01652.
OMAiVLLWNNQ.
OrthoDBiEOG6DJXX1.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39P46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNHPATVSSI AGARKATAAP CHARPRTCGE ALVDLLERHG VECVFGIPGV
60 70 80 90 100
HTVELYRGLA ASSIRHVTPR HEQGAGFMAD GYARVTGRPG VCFIITGPGM
110 120 130 140 150
TNIATAMAQA YADSIPMLVI SSVNARRELG SGDGRLHELP SQRDVFAGLT
160 170 180 190 200
AFSHTLLDAA DLPQVLARAF AVFASARPRP VHIEIPLDVI VMPAPALSDA
210 220 230 240 250
PPALPARPAP DANALAAAAD LLAHARRPLI LAGGGAIHAA AELRELAERL
260 270 280 290 300
HAPVALTINA KGLLPAGHPL LIGSTQSLPA TRAAIRDADV VLAVGTELGE
310 320 330 340 350
TDYDVTFDGG FAIDGRLIRI DIDAQQLMRN ARAEIAIAGD SQLALGALST
360 370 380 390 400
RLHETPAPTP DAGWGAPRVA AVRAAIAATH DSAAQSQALL IDTIVATLPG
410 420 430 440 450
AIIAGDSTSP VYVGNFTHDA PAPRSWFNSS TGYGTLGYGL PAAIGAKLAA
460 470 480 490 500
PARPVVCLIG DGGLQFTLPE LASAVEARLP VIVIVWNNHG YGEIRKYMVA
510 520 530 540 550
RDITPVGVDP YTPDFQVLAR GFGCAAHTAA TPGALAAALR DAAARAIPTV
560
IEIDEATWFG QVQR
Length:564
Mass (Da):58,456
Last modified:November 22, 2005 - v1
Checksum:iE97B79E1BBDE9F7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000150 Genomic DNA. Translation: ABB05770.1.
RefSeqiWP_011349414.1. NC_007509.1.
YP_366414.1. NC_007509.1.

Genome annotation databases

EnsemblBacteriaiABB05770; ABB05770; Bcep18194_C6721.
GeneIDi3733809.
KEGGibur:Bcep18194_C6721.
PATRICi19281464. VBIBurSp120713_0191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000150 Genomic DNA. Translation: ABB05770.1.
RefSeqiWP_011349414.1. NC_007509.1.
YP_366414.1. NC_007509.1.

3D structure databases

ProteinModelPortaliQ39P46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269483.Bcep18194_C6721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB05770; ABB05770; Bcep18194_C6721.
GeneIDi3733809.
KEGGibur:Bcep18194_C6721.
PATRICi19281464. VBIBurSp120713_0191.

Phylogenomic databases

eggNOGiCOG0028.
HOGENOMiHOG000258446.
KOiK01652.
OMAiVLLWNNQ.
OrthoDBiEOG6DJXX1.

Enzyme and pathway databases

BioCyciBSP269483:GHLS-6805-MONOMER.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 3 of Burkholderia sp. 383."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383Imported.

Entry informationi

Entry nameiQ39P46_BURL3
AccessioniPrimary (citable) accession number: Q39P46
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: January 7, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.