Reviewed, UniProtKB/Swiss-Prot Q39M27 (HIS83_BURS3)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 3
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 3

Gene names

Name:	hisC3
Ordered Locus Names:	Bcep18194_C7445

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Histidinol-phosphate aminotransferase 3 HAMAP MF_01023		PRO_0000230210
Amino acid modifications
	Modified residue	233	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q39M27-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: D40D94C1C3418EF2	FASTA	370	40,073
	10 20 30 40 50 60 MQQPWKAVAL SDLPLREDLK LQHAYGAPQL DVPVCLNVNE NPYPPSPALV ERIATAVADA 70 80 90 100 110 120 ARAANRYPDR DFAALRSHLA AYLTHDTGVT VDASSVWAAN GSNEVIQQIL QAFGGPGRSA 130 140 150 160 170 180 LAFTPAYPMY DEYCRTTFTR LHTLPRTEDF ALDLNQALDS IRAHQPGVVL LTSPNNPTGT 190 200 210 220 230 240 ALPIDDIRAI LDAAPGVVVV DEAYAEFRRH GVPSAVTLLP AYPRLIVTRT LSKAFKFAGG 250 260 270 280 290 300 RVGYCACAPA IVEALKLVRL PYHLSAFTQA AACAALVARD EMLSQVEAIK AERDSTVDWL 310 320 330 340 350 360 RGLGLTVADS DANFVMFGEF ADRHRIWSGL LRRGVLIRES GPPPYLRVSI GTGAEMAAFR 370 AALLDVMALE

References

[1]

"Complete sequence of chromosome 3 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000150 Genomic DNA. Translation: ABB06489.1.
RefSeq	YP_367133.1.
3D structure databases
SMR	Q39M27. Positions 8-369.
ModBase	Search...
Protein-protein interaction databases
STRING	Q39M27.
Genome annotation databases
GeneID	3734837.
GenomeReviews	Gene locus Bcep18194_C7445 in contig CP000150_GR.
KEGG	bur:Bcep18194_C7445.
NMPDR	fig|269483.3.peg.3951.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	CPQATLA.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_C7445-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS83_BURS3

Accession

Primary (citable) accession number: Q39M27

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 22, 2005
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)