Q39LI3 (Q39LI3_BURS3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Ordered Locus Names:

Bcep18194_C7639

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800 EMBL ABB06683.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q39LI3 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: ED52F757CA72F5A5	FASTA	409	44,013
	10 20 30 40 50 60 MTTREHCAAL DAADPLAHCR ARFDLPADTI YLDGNSLGAM PANVPARMQR ALQHEWAHGL 70 80 90 100 110 120 IRSWNDADWY PAPQRTGDKI AKLIGAGDGE VIVADSTSVN LFKVLVAATR MRPGRRVILA 130 140 150 160 170 180 ERTNFPTDVY IAASVAEMTG CELRCVDPDD IVAAIDDSVA VVSLTHVNYK SGKRYDMAAV 190 200 210 220 230 240 TRQAHEAGAL SVWDLCHSAG AMPIGLNACD ADFAVGCGYK YLNGGPGAPA YVFVASRHLA 250 260 270 280 290 300 SVRQPLTGWH GHAKPFDFTH DYAPHPAIDR MLTGTAPQLG VIALEAALDA FDGVDLDVLR 310 320 330 340 350 360 DKSVALGDLF IALVDQELAG LGFTLASPRD ATQRGSQVSL AHEQGYAIVQ ALIARNMIGD 370 380 390 400 FRAPDILRFG FAPLYVRYVD VWDTIAALKD VVTSGAWNTD AFLARKSVT

References

[1]

"Complete sequence of chromosome 3 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 383.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000150 Genomic DNA. Translation: ABB06683.1.
RefSeq	YP_367327.1. NC_007509.1.
3D structure databases
ProteinModelPortal	Q39LI3.
SMR	Q39LI3. Positions 2-397.
ModBase	Search...
Protein-protein interaction databases
STRING	Q39LI3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3734506.
GenomeReviews	Gene locus Bcep18194_C7639 in contig CP000150_GR.
KEGG	bur:Bcep18194_C7639.
NMPDR	fig|269483.3.peg.4344.
PATRIC	19283363. VBIBurSp120713_1140.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3844.
HOGENOM	HBG523016.
OMA	NFPTDVY.
ProtClustDB	CLSK769898.
Family and domain databases
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K01556.
PANTHER	PTHR14084. Kynureninase. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01814. Kynureninase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q39LI3_BURS3

Accession

Primary (citable) accession number: Q39LI3

Entry history

Integrated into UniProtKB/TrEMBL:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)