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Q39LH7 (ACDH4_BURS3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 4

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 4
Gene names
Ordered Locus Names:Bcep18194_C7645
OrganismBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]
Taxonomic identifier482957 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Acetaldehyde dehydrogenase 4 HAMAP-Rule MF_01657
PRO_0000387641

Regions

Nucleotide binding15 – 184NAD By similarity
Nucleotide binding164 – 1729NAD By similarity

Sites

Active site1331Acyl-thioester intermediate By similarity
Binding site2921NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q39LH7 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 1035AF1B65B27D5E

FASTA31432,651
        10         20         30         40         50         60 
MMKDLDKLAV AIIGSGNIGT DLMIKVLRHA KHLDVAAMVG IDPASDGLAR AARLGVPTTA 

        70         80         90        100        110        120 
GGIDGLVAMP GFADVRIAFD ATSAGAHARH AEVLGRHGVQ VIDLTPAAIG PFVVPVVNLF 

       130        140        150        160        170        180 
EHLDAPNLNM VTCGGQATIP IVHAVSRVAP VHYAEIVASI SSRSAGPGTR ANIDEFTETT 

       190        200        210        220        230        240 
SKAIETVGGA ARGKAIIVLN PAEPPLMMRD TVYCLTDEDA DTAAIEHSIR TMVDAVASYV 

       250        260        270        280        290        300 
PGYRLKQAVQ FDRYTAAQPL AFDAGERRAG LKVSVFLEVE GAAHYLPSYA GNLDIMTSAA 

       310 
LAAAEQIAAS RVAA 

« Hide

References

[1]"Complete sequence of chromosome 3 of Burkholderia sp. 383."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 383.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000150 Genomic DNA. Translation: ABB06689.1.
RefSeqYP_367333.1. NC_007509.1.

3D structure databases

ProteinModelPortalQ39LH7.
SMRQ39LH7. Positions 7-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING269483.Bcep18194_C7645.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB06689; ABB06689; Bcep18194_C7645.
GeneID3734512.
KEGGbur:Bcep18194_C7645.
PATRIC19283375. VBIBurSp120713_1146.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAHARHEQL.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycBSP269483:GHLS-7729-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH4_BURS3
AccessionPrimary (citable) accession number: Q39LH7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 22, 2005
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families