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Protein

Acetaldehyde dehydrogenase 4

Gene

Bcep18194_C7645

Organism
Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Acyl-thioester intermediateUniRule annotation1
Binding sitei292NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 18NADUniRule annotation4
Nucleotide bindingi164 – 172NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 4UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 4UniRule annotation
Gene namesi
Ordered Locus Names:Bcep18194_C7645
OrganismiBurkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876411 – 314Acetaldehyde dehydrogenase 4Add BLAST314

Structurei

3D structure databases

ProteinModelPortaliQ39LH7.
SMRiQ39LH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149.
KOiK04073.
OMAiMIKVIRH.
OrthoDBiPOG091H09NP.

Family and domain databases

HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiView protein in InterPro
IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
PfamiView protein in Pfam
PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39LH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKDLDKLAV AIIGSGNIGT DLMIKVLRHA KHLDVAAMVG IDPASDGLAR
60 70 80 90 100
AARLGVPTTA GGIDGLVAMP GFADVRIAFD ATSAGAHARH AEVLGRHGVQ
110 120 130 140 150
VIDLTPAAIG PFVVPVVNLF EHLDAPNLNM VTCGGQATIP IVHAVSRVAP
160 170 180 190 200
VHYAEIVASI SSRSAGPGTR ANIDEFTETT SKAIETVGGA ARGKAIIVLN
210 220 230 240 250
PAEPPLMMRD TVYCLTDEDA DTAAIEHSIR TMVDAVASYV PGYRLKQAVQ
260 270 280 290 300
FDRYTAAQPL AFDAGERRAG LKVSVFLEVE GAAHYLPSYA GNLDIMTSAA
310
LAAAEQIAAS RVAA
Length:314
Mass (Da):32,651
Last modified:November 22, 2005 - v1
Checksum:i1035AF1B65B27D5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000150 Genomic DNA. Translation: ABB06689.1.
RefSeqiWP_011350331.1. NC_007509.1.

Genome annotation databases

EnsemblBacteriaiABB06689; ABB06689; Bcep18194_C7645.
KEGGibur:Bcep18194_C7645.
PATRICifig|482957.22.peg.8261.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACDH4_BURL3
AccessioniPrimary (citable) accession number: Q39LH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 22, 2005
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families