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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Bcep18194_A3323
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002271001 – 975Glycine dehydrogenase (decarboxylating)Add BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei723N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ39KU1
SMRiQ39KU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.102 hits
3.90.1150.101 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q39KU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLEHPDRLM NRTPLSLAAL ETHDAFAERH IGPDAASQQA MLDTLGFASR
60 70 80 90 100
AALIDAVIPA SIRRAETLPL GPFAQPKSEA EALAALRVLA DKNEVFRSYI
110 120 130 140 150
GQGYHDTHTP AVILRNVLEN PAWYTAYTPY QPEISQGRLE ALLNFQQMVA
160 170 180 190 200
DLTGLAISNA SLLDEATAAA EAMTLLQRTG KPTSNVFYVA DDVLPQTLEV
210 220 230 240 250
IRTRALPVGI EVKTGPAADA AQANAFGVLL QYPGVNGDVR DYRALTEAIH
260 270 280 290 300
AAGGHVVVAA DLLALTVLTP PGDWGADVAI GNTQRFGVPM GFGGPHAAYL
310 320 330 340 350
AVRDEFKRQM PGRLVGVTVD AQGKPALRLA LQTREQHIRR EKATSNVCTA
360 370 380 390 400
QALLAIMASM YAVYHGPHGL KTIALRVNRI AALLAAGVKQ LGFATVNDTF
410 420 430 440 450
FDTLTIDTGA RTAQVHEFAK AKRINLRRVS DTQVGVSVDE TTTRDDLADL
460 470 480 490 500
LAVFAQAAGG TAPAVDALDA GLAGVAALPA GLERTSAYLT HHVFNRHHSE
510 520 530 540 550
TEMLRYLRSL SDKDLALDRS MIPLGSCTMK LNATSEMLPV TWPEFGGIHP
560 570 580 590 600
FAPAEQTVGY REMIDQLEQM LVAATGYAAV SLQPNAGSQG EYAGLLIIHA
610 620 630 640 650
YHASRGEAHR DVCLIPASAH GTNPASAHMA GMKVVVVACD AQGNVDIADL
660 670 680 690 700
KAKADEHAKD LAAIMITYPS THGVFEQNVR EICEIVHAHG GQVYVDGANM
710 720 730 740 750
NAMVGLTAPG QFGGDVSHLN LHKTFCIPHG GGGPGVGPVA VGAHLAKFLP
760 770 780 790 800
NQRSTGYTRE EDGIGAVSAA PYGSASILPI SWMYIAMMGA KNLTAATETA
810 820 830 840 850
ILNANYIAKR LAPHYPVLYS GPGGLVAHEC ILDLRPIKES SGISVDDVAK
860 870 880 890 900
RLMDYGFHAP TMSFPVPGTL MVEPTESESQ EELDRFIAAM IAIRDEIRAV
910 920 930 940 950
EEGRADREDN PLRHAPHTAA VVTANEWLHA YSREQAAYPV ASLGTNKYWP
960 970
PVGRADNVYG DRNLFCSCVP MSEYA
Length:975
Mass (Da):104,270
Last modified:November 22, 2005 - v1
Checksum:iDF25F2E666424984
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA Translation: ABB06925.1
RefSeqiWP_011350561.1, NC_007510.1

Genome annotation databases

EnsemblBacteriaiABB06925; ABB06925; Bcep18194_A3323
KEGGibur:Bcep18194_A3323
PATRICifig|482957.22.peg.156

Similar proteinsi

Entry informationi

Entry nameiGCSP_BURL3
AccessioniPrimary (citable) accession number: Q39KU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 22, 2005
Last modified: February 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome