Reviewed, UniProtKB/Swiss-Prot Q39KT9 (GCST_BURS3)

Names and origin

Protein names

Recommended name:
    Aminomethyltransferase
    EC=2.1.2.10
Alternative name(s):
    Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Bcep18194_A3325

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity.
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the gcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Aminomethyltransferase HAMAP MF_00259		PRO_1000047652

Sequences

	Sequence		Length	Mass (Da)
	Q39KT9-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 1087F6A6FC3E76A5	FASTA	372	40,002
	10 20 30 40 50 60 MTALNHTPLN AAHRALNARM VDFGGWDMPV NYGSQIEEHE AVRTDAGMFD VSHMCVVDFT 70 80 90 100 110 120 GSRVRAFFEH AIANNVGKLK TPGKALYSCL LNPQGGVIDD LIVYYFTEEF FRVVVNAGTA 130 140 150 160 170 180 EKDIAWFNQL NEQGGFGVTI TPRRDFAIVA VQGPNAREKA WSTVPAARAA TSELKPFNAA 190 200 210 220 230 240 QVAGTPFGDL TVARTGYTGE DGFEVIVPAV HVEALWNALQ QNGVRPCGLG ARDTLRLEAG 250 260 270 280 290 300 MNLYGQDMDD TVSPLDAGLA WTVDLTAPRD FVGRAALEAN GTRAAFVGLI LQKENGKAGG 310 320 330 340 350 360 VLRAHQKVVT PHGEGEITSG TFSPSMQESI AFARVPAAVQ IGDLVQVQIR DKNLPARVVK 370 LPFVRNGKVL AA

References

[1]

"Complete sequence of chromosome 1 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000151 Genomic DNA. Translation: ABB06927.1.
RefSeq	YP_367571.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q39KT9.
Genome annotation databases
GeneID	3748491.
GenomeReviews	Gene locus Bcep18194_A3325 in contig CP000151_GR.
KEGG	bur:Bcep18194_A3325.
NMPDR	fig|269483.3.peg.4424.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q39KT9.
OMA	VEIRGKW.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_A3325-MON.
Family and domain databases
HAMAP	MF_00259. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. gcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BURS3

Accession

Primary (citable) accession number: Q39KT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)