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Protein

Chemotaxis response regulator protein-glutamate methylesterase 3

Gene

cheB3

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176UniRule annotation1
Active sitei202UniRule annotation1
Active sitei298UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 3UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB3UniRule annotation
Ordered Locus Names:Bcep18194_A3363
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002254511 – 363Chemotaxis response regulator protein-glutamate methylesterase 3Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ39KQ1.
SMRiQ39KQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 125Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini164 – 356CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000151423.
KOiK03412.
OMAiMLEMHRA.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39KQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVQKIKVL CVDDSALIRS LMTEIINSQP DMTVCATAPD PLVARELIKQ
60 70 80 90 100
HNPDVLTLDV EMPRMDGLDF LEKLMRLRPM PVVMVSSLTE RGSEITLRAL
110 120 130 140 150
ELGAVDFVTK PRVGIRDGML DYAEKLADKI RAASRARVRQ APQPQAVARA
160 170 180 190 200
ADSHPAAPMI NNPLVSTEKL IIIGASTGGT EAIREVLTPL PPDAPAVLIA
210 220 230 240 250
QHMPPGFTKS FAQRLNGLCR IAVKEAEHGE RVLPGHAYIA PGHAHLLLAR
260 270 280 290 300
SGANYIAQLS DEPPVNRHRP SVDVLFRSAA THAGKNAIGV ILTGMGRDGA
310 320 330 340 350
AGLLEMKRAG AHTFAQDEAS CIVFGMPREA IALGGADEIV PLAEMSRRVM
360
ARLATMGDRV QRV
Length:363
Mass (Da):39,053
Last modified:November 22, 2005 - v1
Checksum:i01C94B5F16BC9AB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB06965.1.
RefSeqiWP_011350600.1. NC_007510.1.

Genome annotation databases

EnsemblBacteriaiABB06965; ABB06965; Bcep18194_A3363.
KEGGibur:Bcep18194_A3363.
PATRICifig|482957.22.peg.200.

Similar proteinsi

Entry informationi

Entry nameiCHEB3_BURL3
AccessioniPrimary (citable) accession number: Q39KQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 22, 2005
Last modified: November 22, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome