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Reviewed, UniProtKB/Swiss-Prot Q39KC4 (AROB_BURS3)

Last modified November 3, 2009. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4
Gene names
Name: aroB
Ordered Locus Names: Bcep18194_A3490
OrganismBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]
Taxonomic identifier269483 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

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Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity.

NAD By similarity.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the dehydroquinate synthase family.

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Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3593593-dehydroquinate synthase HAMAP MF_00110
PRO_0000231076

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Sequences

Sequence LengthMass (Da)Tools
Q39KC4-1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 1584F3AB760E40EB

FASTA35937,874
        10         20         30         40         50         60 
MITVNVDLGD RAYPIHIGAG LIGRAELFAP HIKGSSVTIV TNTTVDPLYG DALRAALAPL 

        70         80         90        100        110        120 
GKRVSTVVLP DGEAYKNWET LNLIFDGLLT DRADRKTTLV ALGGGVVGDM TGFAAACYMR 

       130        140        150        160        170        180 
GVPFIQVPTT LLSQVDSSVG GKTGINHPLG KNMIGAFYQP QAVIADIGAL TTLPDRELAA 

       190        200        210        220        230        240 
GVAEIIKTGA IADAEFFDWI EANVDALNRR DPAALAHAVK RSCEIKASVV AADEREGGLR 

       250        260        270        280        290        300 
AILNFGHTFG HAIEAGLGYG EWLHGEAVGC GMVMAGDLSV RLGLLDEASR QRLDAVIAAA 

       310        320        330        340        350 
HLPTRGPALG DARYLDLMRV DKKAEAGAIK FILLKRFGDT LITQAPDEAV FATLAQTTH

« Hide

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References

[1]"Complete sequence of chromosome 1 of Burkholderia sp. 383."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000151 Genomic DNA. Translation: ABB07092.1.
RefSeqYP_367736.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ39KC4.

Genome annotation databases

GeneID3748667.
GenomeReviewsGene locus Bcep18194_A3490 in contig CP000151_GR.
KEGGbur:Bcep18194_A3490.
NMPDRfig|269483.3.peg.4764.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ39KC4.
OMAEDYLPHM.

Enzyme and pathway databases

BioCycBSP36773:BCEP18194_A3490-MON.

Family and domain databases

HAMAPMF_00110.
[Tree]
InterProIPR016303. DHQ_synth.
IPR002658. DHQ_synth_AroB.
IPR016037. DHQ_synth_AroB_sub.
[Graphical view]
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PfamPF01761. DHQ_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. aroB. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameAROB_BURS3
AccessionPrimary (citable) accession number: Q39KC4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 22, 2005
Last modified: November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents