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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE), Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI), Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA), 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB), Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase 3 (hisC3), Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase 1 (hisC1), Histidinol-phosphate aminotransferase 2 (hisC2), Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD), Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138NADUniRule annotation1
Binding sitei199NADUniRule annotation1
Binding sitei222NADUniRule annotation1
Binding sitei245SubstrateUniRule annotation1
Metal bindingi267ZincUniRule annotation1
Binding sitei267SubstrateUniRule annotation1
Metal bindingi270ZincUniRule annotation1
Binding sitei270SubstrateUniRule annotation1
Active sitei335Proton acceptorUniRule annotation1
Active sitei336Proton acceptorUniRule annotation1
Binding sitei336SubstrateUniRule annotation1
Metal bindingi369ZincUniRule annotation1
Binding sitei369SubstrateUniRule annotation1
Binding sitei423SubstrateUniRule annotation1
Metal bindingi428ZincUniRule annotation1
Binding sitei428SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Bcep18194_A3523
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002298531 – 438Histidinol dehydrogenaseAdd BLAST438

Proteomic databases

PRIDEiQ39K91

Structurei

3D structure databases

ProteinModelPortaliQ39K91
SMRiQ39K91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG091H03YX

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q39K91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITIRKLDS TSAGFGAELR ALLAFEASED AAIEQSVAQI LADVKSRGDA
60 70 80 90 100
AVLEYTNRFD RLSASSIAAL ELPQDALQTA LDSLAPKARA ALEAAAARVR
110 120 130 140 150
AYHEKQKIEC GTHSWQYTES DGTVLGQKVT PLDRVGLYVP GGKAAYPSSV
160 170 180 190 200
LMNAIPARVA GVGEIVMVVP TPDGVKNDLV LAAALLGGVD RVFTIGGAQA
210 220 230 240 250
VGALAYGTAT VPAVDKICGP GNAYVASAKR RVFGTVGIDM IAGPSEILVL
260 270 280 290 300
CDGTTDPNWV AMDLFSQAEH DELAQSILLC PDGAFLERVE KAIDELLPSM
310 320 330 340 350
PRQDVIRASL EGRGALIKVR DMAEACRIAN DIAPEHLEIS ALEPQQWGQQ
360 370 380 390 400
IRHAGAIFLG RYTSESLGDY CAGPNHVLPT SRTARFSSPL GVYDFIKRSS
410 420 430
LIEVSAEGAQ TLGEIASELA YGEGLQAHAK SAEFRMKH
Length:438
Mass (Da):46,414
Last modified:November 22, 2005 - v1
Checksum:i2CD2FBB3520628C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA Translation: ABB07125.1
RefSeqiWP_011350726.1, NC_007510.1

Genome annotation databases

EnsemblBacteriaiABB07125; ABB07125; Bcep18194_A3523
KEGGibur:Bcep18194_A3523
PATRICifig|482957.22.peg.368

Similar proteinsi

Entry informationi

Entry nameiHISX_BURL3
AccessioniPrimary (citable) accession number: Q39K91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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