Reviewed, UniProtKB/Swiss-Prot Q39K90 (HIS81_BURS3)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	Bcep18194_A3524

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000230208
Amino acid modifications
	Modified residue	217	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q39K90-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 3ABCEE2FD52C8002	FASTA	357	38,404
	10 20 30 40 50 60 MTTPQDIIRR DVLAMTSYPV PDASGFVKLD AMENPYPLPE PLAAALGERL AQVALNRYPA 70 80 90 100 110 120 PRPAALLDKL RHAMGVPAGC EVLLGNGSDE IISMMSMACA KPGAKVLAPV PGFVMYELSA 130 140 150 160 170 180 KLAQLEFVGV PLKADLTLDV DAMLAAIAEH RPAIVYLAYP NNPTGTLYDD ADIERIVAAA 190 200 210 220 230 240 RHSLIVIDEA YQPFAVRSWL PRAAEFDNVV VMRTVSKLGL AGIRLGYLVG SPAWLTEFDK 250 260 270 280 290 300 VRPPYNINVL TQATADFLLD HLDVLDAQAA DLRAERTRLA QEVAALPGTT VFPSAGNFLL 310 320 330 340 350 VRVPDAAAVF DALLTERVLV KNVSKMHPLL AECVRLTVGS PDENARLLAA LKLALPG

References

[1]

"Complete sequence of chromosome 1 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000151 Genomic DNA. Translation: ABB07126.1.
RefSeq	YP_367770.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q39K90.
Genome annotation databases
GeneID	3748701.
GenomeReviews	Gene locus Bcep18194_A3524 in contig CP000151_GR.
KEGG	bur:Bcep18194_A3524.
NMPDR	fig|269483.3.peg.4828.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q39K90.
OMA	PEQLLIG.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_A3524-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_BURS3

Accession

Primary (citable) accession number: Q39K90

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)