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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC:2.7.8.13)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene namesi
Name:mraY
Ordered Locus Names:Bcep18194_A3642
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane ; Multi-pass membrane protein

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalAdd BLAST21
Transmembranei73 – 93HelicalAdd BLAST21
Transmembranei97 – 117HelicalAdd BLAST21
Transmembranei135 – 155HelicalAdd BLAST21
Transmembranei190 – 210HelicalAdd BLAST21
Transmembranei222 – 242HelicalAdd BLAST21
Transmembranei258 – 278HelicalAdd BLAST21
Transmembranei286 – 306HelicalAdd BLAST21
Transmembranei311 – 331HelicalAdd BLAST21
Transmembranei366 – 386HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002354421 – 389Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST389

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39JX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLALAQWLQ GDASFLRLFT YLTFRAVMAT ITALGIGLVC GPWVIRKLTQ
60 70 80 90 100
MKVGQAVRKD GPQTHLVKSG TPTMGGVLIL IGIAVATLLW GDLTNRFIWI
110 120 130 140 150
VMLVTFGFGV IGWVDDYRKV VHKDPRGMSS REKYFWQSVI GLFAAVYLAF
160 170 180 190 200
SVSEANNVRV FDLFMAWVRS GLSMGLPARA DLMLPFLKSI SYPLGVWGFI
210 220 230 240 250
VLTYFVIVGA SNAVNLTDGL DGLVIMPVVL VGASLGVFAY VMGSAVYSKY
260 270 280 290 300
LLFPHIPGAG ELLIFCSAMG GAGLAFLWYN THPAQVFMGD VGALALGGAL
310 320 330 340 350
GTVAVIVRQE IVLFIMGGIF VAETLSVMLQ VSWFKYTKKR YGEGRRLLKM
360 370 380
APLHHHFELS GWKETQVVVR FWIITLMLCL FGLTTLKLR
Length:389
Mass (Da):42,808
Last modified:November 22, 2005 - v1
Checksum:i4717CF0183877833
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB07243.1.
RefSeqiWP_006477019.1. NZ_LDWP01000061.1.

Genome annotation databases

EnsemblBacteriaiABB07243; ABB07243; Bcep18194_A3642.
GeneIDi29780539.
KEGGibur:Bcep18194_A3642.

Similar proteinsi

Entry informationi

Entry nameiMRAY_BURL3
AccessioniPrimary (citable) accession number: Q39JX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 22, 2005
Last modified: October 25, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families