Reviewed, UniProtKB/Swiss-Prot Q39IU8 (UPPP1_BURS3)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Ordered Locus Names:	Bcep18194_A4021

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000227610
Regions
	Transmembrane	4 – 24	21	Potential
	Transmembrane	46 – 63	18	Potential
	Transmembrane	83 – 103	21	Potential
	Transmembrane	108 – 128	21	Potential
	Transmembrane	187 – 207	21	Potential
	Transmembrane	217 – 237	21	Potential
	Transmembrane	252 – 272	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q39IU8-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 64C1BA336580B914	FASTA	276	30,354
	10 20 30 40 50 60 MDWILICKAL ILGVVEGLTE FLPVSSTGHL IVAGSFLNFN DSHAKTFDVV IQFGAILAVC 70 80 90 100 110 120 WEYRQRIASI VSGLPSRPDA RRFTLNVVIA TIPAIALGLL FEKKIKAVLF SPVPVAFALV 130 140 150 160 170 180 VGGAIILWAE ARQRERREPP RVMSVDELTP LDALKVGIAQ CFALIPGMSR SGSTIIGGML 190 200 210 220 230 240 FGLDRRVATE FSFFLAIPII FGATLYETVK DWQAFTVDSL GLFVLGAVAA FVSAFVCVRW 250 260 270 LLRYVASHDF TVFAWYRIAF GLFVLLVGYS GWLNWA

References

[1]

"Complete sequence of chromosome 1 of Burkholderia sp. 383." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000151 Genomic DNA. Translation: ABB07618.1.
RefSeq	YP_368262.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q39IU8.
Genome annotation databases
GeneID	3749206.
GenomeReviews	Gene locus Bcep18194_A4021 in contig CP000151_GR.
KEGG	bur:Bcep18194_A4021.
NMPDR	fig|269483.3.peg.4896.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q39IU8.
OMA	THDPRAN.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_A4021-MON.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP1_BURS3

Accession

Primary (citable) accession number: Q39IU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)