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Q39IU7

- TRMB_BURS3

UniProt

Q39IU7 - TRMB_BURS3

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, Bcep18194_A4022
Organism
Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861S-adenosyl-L-methionine By similarity
Binding sitei111 – 1111S-adenosyl-L-methionine By similarity
Binding sitei138 – 1381S-adenosyl-L-methionine By similarity
Active sitei161 – 1611 By similarity
Binding sitei161 – 1611S-adenosyl-L-methionine By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei197 – 1971Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBSP269483:GHLS-863-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:Bcep18194_A4022
    OrganismiBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
    Taxonomic identifieri482957 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002705: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000229158Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269483.Bcep18194_A4022.

    Structurei

    3D structure databases

    ProteinModelPortaliQ39IU7.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni232 – 2354Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiHSTLEMA.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q39IU7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMHDDPNEAG LPPHDDAIPD EAAEGADAVN PLHHRRIRSF VTRAGRVSTG    50
    QRRAMDELGP RFVVPYAPEL PDWNAVFGRS APRILEIGFG MGASTAEIAA 100
    NRPGDDFLGV EVHEPGVGAL LKLIGEQDLS NIRIIQHDAV EVLEHMLAPE 150
    SLDGVHIFFP DPWHKARHHK RRLIQPPLVA HLVSRLKPGA YIHCATDWQN 200
    YAEQMLEVLG AEPTLENTAA DYAPRPDYRP VTKFERRGLR LGHGVWDLVF 250
    RKRAA 255
    Length:255
    Mass (Da):28,439
    Last modified:November 22, 2005 - v1
    Checksum:i9E577C0E58B60B5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000151 Genomic DNA. Translation: ABB07619.1.
    RefSeqiWP_011351200.1. NC_007510.1.
    YP_368263.1. NC_007510.1.

    Genome annotation databases

    EnsemblBacteriaiABB07619; ABB07619; Bcep18194_A4022.
    GeneIDi3749207.
    KEGGibur:Bcep18194_A4022.
    PATRICi19285370. VBIBurSp120713_2117.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000151 Genomic DNA. Translation: ABB07619.1 .
    RefSeqi WP_011351200.1. NC_007510.1.
    YP_368263.1. NC_007510.1.

    3D structure databases

    ProteinModelPortali Q39IU7.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 269483.Bcep18194_A4022.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB07619 ; ABB07619 ; Bcep18194_A4022 .
    GeneIDi 3749207.
    KEGGi bur:Bcep18194_A4022.
    PATRICi 19285370. VBIBurSp120713_2117.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi HSTLEMA.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci BSP269483:GHLS-863-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia sp. 383."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 383.

    Entry informationi

    Entry nameiTRMB_BURS3
    AccessioniPrimary (citable) accession number: Q39IU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 22, 2005
    Last modified: September 3, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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