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Q39IQ1

- GLK_BURS3

UniProt

Q39IQ1 - GLK_BURS3

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Protein

Bifunctional protein glk

Gene
glk, Bcep18194_A4068
Organism
Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 286ATP Reviewed prediction
DNA bindingi377 – 39620H-T-H motif By similarityAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. carbohydrate binding Source: InterPro
  3. DNA binding Source: UniProtKB-KW
  4. glucokinase activity Source: UniProtKB-EC
  5. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSP269483:GHLS-910-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein glk
Including the following 2 domains:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Putative HTH-type transcriptional regulator
Gene namesi
Name:glk
Ordered Locus Names:Bcep18194_A4068
OrganismiBurkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194))
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002705: Chromosome 1

Subcellular locationi

Membrane; Single-pass membrane protein Reviewed prediction UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei576 – 59621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Bifunctional protein glkUniRule annotationPRO_0000268800Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269483.Bcep18194_A4068.

Structurei

3D structure databases

ProteinModelPortaliQ39IQ1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini341 – 41777HTH rpiR-typeAdd
BLAST
Domaini461 – 600140SISAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 340340GlucokinaseUniRule annotationAdd
BLAST
Regioni341 – 642302Putative HTH-type transcriptional regulatorUniRule annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the bacterial glucokinase family.
Contains 1 SIS domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1737.
HOGENOMiHOG000257466.
KOiK00845.
OMAiQYARKKW.
OrthoDBiEOG64BQ47.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00524. Glucokinase.
InterProiIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR00749. glk. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39IQ1-1 [UniParc]FASTAAdd to Basket

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MSTGAQSKAA VAGQHADGPR LLADVGGTNA RFALETGPGD ITQIRVYPGA    50
DYPTLTDAIR KYLKDVKITR VNHAAIAIAN PVDGDQVTMT NHDWSFSIEA 100
TRRALGFDTL LVVNDFTALA MALPGLTDAQ RVQIGGGARR QNSVIGLLGP 150
GTGLGVSGLI PADDRWIALG SEGGHASFAP QDEREDLVLQ YARKKFPHVS 200
FERVCAGPGM EIIYRALAAR DKKRVAATVD TVEIVERAHA GDALALETVE 250
CFCGILGAFA GSVALTLGAL GGVYIGGGVA LKLGELFTRS SFRARFEAKG 300
RFTHYLENIP TYLITAEYPA FLGVSAILAE QLSNRSGGAS SAVFERIRQM 350
RDALTPAERR VADLALNHPR SIINDPIVDI ARKADVSQPT VIRFCRSLGC 400
QGLSDFKLKL ATGLTGTIPM SHSQVHLGDT ATDFGAKVLD NTVSAILQLR 450
EHLNFEHVEN AIEILNGARR IEFYGLGNSN IVAQDAHYKF FRFGIPTIAY 500
GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ AGAKVIAITS 550
SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLLMIDIL AVGVAIRRAS 600
TNGELPEAVA QAKARASDDE TADVLDWLSH GASPAAKDVA RD 642
Length:642
Mass (Da):68,507
Last modified:November 22, 2005 - v1
Checksum:i79F479F63D4FEF3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000151 Genomic DNA. Translation: ABB07665.1.
RefSeqiWP_011351246.1. NC_007510.1.
YP_368309.1. NC_007510.1.

Genome annotation databases

EnsemblBacteriaiABB07665; ABB07665; Bcep18194_A4068.
GeneIDi3749254.
KEGGibur:Bcep18194_A4068.
PATRICi19285462. VBIBurSp120713_2162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000151 Genomic DNA. Translation: ABB07665.1 .
RefSeqi WP_011351246.1. NC_007510.1.
YP_368309.1. NC_007510.1.

3D structure databases

ProteinModelPortali Q39IQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269483.Bcep18194_A4068.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB07665 ; ABB07665 ; Bcep18194_A4068 .
GeneIDi 3749254.
KEGGi bur:Bcep18194_A4068.
PATRICi 19285462. VBIBurSp120713_2162.

Phylogenomic databases

eggNOGi COG1737.
HOGENOMi HOG000257466.
KOi K00845.
OMAi QYARKKW.
OrthoDBi EOG64BQ47.

Enzyme and pathway databases

BioCyci BSP269483:GHLS-910-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_00524. Glucokinase.
InterProi IPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
TIGRFAMsi TIGR00749. glk. 1 hit.
PROSITEi PS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia sp. 383."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 383.

Entry informationi

Entry nameiGLK_BURS3
AccessioniPrimary (citable) accession number: Q39IQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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