Q39IL2 (KGUA_BURS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	Bcep18194_A4107

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000266297
Regions
	Domain	21 – 199	179	Guanylate kinase-like
	Nucleotide binding	28 – 35	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q39IL2 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 314ED4AA15B44915	FASTA	227	25,419
	10 20 30 40 50 60 MTQSTHDGHA AHSLHGGVYP GNLFMVVAPS GAGKSTLVNA LLSKDSDICL SISYTTRKPR 70 80 90 100 110 120 PGEQDGQHYH FTTVEDFRTR HAAHEFLESA EVHGNYYGTS RVWIEEQMKN GHDVLLEIDW 130 140 150 160 170 180 QGALQVKKQF RNAVGIFILP PSLDALEERL KKRGQDEPKV ITRRLLAAGS EIAHAPEAEY 190 200 210 220 VVINENFERA LAELECIVAA TRLRFASQYA RHTELFIELG IHLPHAE

References

[1]

"Complete sequence of chromosome 1 of Burkholderia sp. 383." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 383.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000151 Genomic DNA. Translation: ABB07704.1.
RefSeq	YP_368348.1. NC_007510.1.
3D structure databases
HSSP	HSSP built from PDB template 2ANC based on UniProtKB P60546.
ProteinModelPortal	Q39IL2.
ModBase	Search...
Protein-protein interaction databases
STRING	269483.Bcep18194_A4107.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB07704; ABB07704; Bcep18194_A4107.
GeneID	3749295.
KEGG	bur:Bcep18194_A4107.
PATRIC	19285550. VBIBurSp120713_2204.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HOG000037638.
KO	K00942.
OMA	EWAEFAG.
ProtClustDB	PRK00300.
Enzyme and pathway databases
BioCyc	BSP269483:GHLS-4187-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_BURS3

Accession

Primary (citable) accession number: Q39IL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program