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Protein

Inositol 2-dehydrogenase

Gene

iolG

Organism
Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).UniRule annotation

Catalytic activityi

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSP269483:GHLS-1429-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 2-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation)
Alternative name(s):
Myo-inositol 2-dehydrogenaseUniRule annotation
Short name:
MI 2-dehydrogenaseUniRule annotation
Gene namesi
Name:iolGUniRule annotation
Ordered Locus Names:Bcep18194_A4572
OrganismiBurkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003525641 – 337Inositol 2-dehydrogenaseAdd BLAST337

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ39H98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227439.
KOiK00010.
OMAiACCEAGV.
OrthoDBiPOG091H0FNG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG. 1 hit.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39H98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLQIGVIGC GAIGQDHIRR LTRTLSGARV VAVNDIDPQQ ARDAVTKYGL
60 70 80 90 100
DAEIYGDGHE VVAAADVQAV LVTSWGPTHE AFVLDAIAHG KPVFCEKPLA
110 120 130 140 150
VTAEGCMRIV EAEVAHGKRL VQVGFMRPYD EGYRALKRVI DSGEIGAPLM
160 170 180 190 200
LHCAHRNQSV GERYTTDMAI TDTLIHELDV LRWLLGEDYV STQVVYPKKT
210 220 230 240 250
RHASSHLADP QIVLLETASG VRIDVEIFVN CQYGYDIQCE VVGEQGIAKL
260 270 280 290 300
PDPPAVGLKH GARQSVEIMT DWKERFIASY DVELQAFIDG VRAHALTGPS
310 320 330
AWDGYAAAVA ADACVRAQKS GAVEPIAMAE RPAFYRG
Length:337
Mass (Da):36,631
Last modified:November 22, 2005 - v1
Checksum:i4EB1035E0247A917
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB08168.1.
RefSeqiWP_011351738.1. NC_007510.1.

Genome annotation databases

EnsemblBacteriaiABB08168; ABB08168; Bcep18194_A4572.
KEGGibur:Bcep18194_A4572.
PATRICi19286534. VBIBurSp120713_2682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB08168.1.
RefSeqiWP_011351738.1. NC_007510.1.

3D structure databases

ProteinModelPortaliQ39H98.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB08168; ABB08168; Bcep18194_A4572.
KEGGibur:Bcep18194_A4572.
PATRICi19286534. VBIBurSp120713_2682.

Phylogenomic databases

HOGENOMiHOG000227439.
KOiK00010.
OMAiACCEAGV.
OrthoDBiPOG091H0FNG.

Enzyme and pathway databases

BioCyciBSP269483:GHLS-1429-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG. 1 hit.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIOLG_BURL3
AccessioniPrimary (citable) accession number: Q39H98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.