Q39H98 (IOLG_BURS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Bcep18194_A4572

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352564

Sequences

	Sequence		Length	Mass (Da)
	Q39H98 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 4EB1035E0247A917	FASTA	337	36,631
	10 20 30 40 50 60 MTLQIGVIGC GAIGQDHIRR LTRTLSGARV VAVNDIDPQQ ARDAVTKYGL DAEIYGDGHE 70 80 90 100 110 120 VVAAADVQAV LVTSWGPTHE AFVLDAIAHG KPVFCEKPLA VTAEGCMRIV EAEVAHGKRL 130 140 150 160 170 180 VQVGFMRPYD EGYRALKRVI DSGEIGAPLM LHCAHRNQSV GERYTTDMAI TDTLIHELDV 190 200 210 220 230 240 LRWLLGEDYV STQVVYPKKT RHASSHLADP QIVLLETASG VRIDVEIFVN CQYGYDIQCE 250 260 270 280 290 300 VVGEQGIAKL PDPPAVGLKH GARQSVEIMT DWKERFIASY DVELQAFIDG VRAHALTGPS 310 320 330 AWDGYAAAVA ADACVRAQKS GAVEPIAMAE RPAFYRG

References

[1]

"Complete sequence of chromosome 1 of Burkholderia sp. 383." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 383.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000151 Genomic DNA. Translation: ABB08168.1.
RefSeq	YP_368812.1. NC_007510.1.
3D structure databases
ProteinModelPortal	Q39H98.
ModBase	Search...
Protein-protein interaction databases
STRING	Q39H98.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3749773.
GenomeReviews	Gene locus Bcep18194_A4572 in contig CP000151_GR.
KEGG	bur:Bcep18194_A4572.
NMPDR	fig|269483.3.peg.5805.
PATRIC	19286534. VBIBurSp120713_2682.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	YDVELQD.
ProtClustDB	CLSK896889.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_A4572-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_BURS3

Accession

Primary (citable) accession number: Q39H98

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program