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Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei157 – 1571UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBSP269483:GHLS-1986-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferaseUniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferaseUniRule annotation
Protein L-isoaspartyl methyltransferaseUniRule annotation
Protein-beta-aspartate methyltransferaseUniRule annotation
Short name:
PIMTUniRule annotation
Gene namesi
Name:pcmUniRule annotation
Ordered Locus Names:Bcep18194_A5123
OrganismiBurkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Protein-L-isoaspartate O-methyltransferasePRO_0000351838Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ39FP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000257189.
KOiK00573.
OMAiAWMSSGK.
OrthoDBiPOG091H06AY.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q39FP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGERAKRFP LALEDLKRAP RKSEGRAGER HAAVAGSKAA DKPAAVLKPV
60 70 80 90 100
AVKPAAVRTA LPGSAAAKPA TAPKPTALKP AMPKPAAPSV APAGAFALTS
110 120 130 140 150
ERVRERMVER LRANGVTDAR VLEAMAAVPR HMFVDPGLAT QAYEDSALPI
160 170 180 190 200
GHQQTISKPS VVARMIELAM AGRTLERVLE IGTGCGYQAA VLSHVARDVY
210 220 230 240 250
SIERIKPLYE RAKLNLRPLR VPNIRLHYGD GRVGLPSAAP FDAIVIAAAG
260 270 280 290 300
LDVPQALLEQ LAIGGRLVAP VGAQSGQHQV LTLVERVAHA QWRESRLDRV
310
FFVPLKSGVI
Length:310
Mass (Da):32,926
Last modified:November 22, 2005 - v1
Checksum:i7B1A2AA86240BD11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB08717.1.
RefSeqiWP_011352272.1. NC_007510.1.

Genome annotation databases

EnsemblBacteriaiABB08717; ABB08717; Bcep18194_A5123.
KEGGibur:Bcep18194_A5123.
PATRICi19287637. VBIBurSp120713_3223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB08717.1.
RefSeqiWP_011352272.1. NC_007510.1.

3D structure databases

ProteinModelPortaliQ39FP9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB08717; ABB08717; Bcep18194_A5123.
KEGGibur:Bcep18194_A5123.
PATRICi19287637. VBIBurSp120713_3223.

Phylogenomic databases

HOGENOMiHOG000257189.
KOiK00573.
OMAiAWMSSGK.
OrthoDBiPOG091H06AY.

Enzyme and pathway databases

BioCyciBSP269483:GHLS-1986-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIMT_BURL3
AccessioniPrimary (citable) accession number: Q39FP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.