Q39FP8 (SURE2_BURS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE 2
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase 2

Gene names

Name:	surE2
Ordered Locus Names:	Bcep18194_A5124

Organism

Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP]

Taxonomic identifier

269483 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	5'-nucleotidase surE 2 HAMAP MF_00060		PRO_0000235601
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	39	1	Divalent metal cation By similarity
	Metal binding	92	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q39FP8 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: DF1E9E2C627AEF0D	FASTA	253	26,768
	10 20 30 40 50 60 MRILLSNDDG YLAPGLAALS DALQPLAELT VIAPEQNCSG ASNSLTLSRP LSVQRAASTG 70 80 90 100 110 120 FFYVNGTPTD SVHVALTGMA DARPDLVVSG INNGQNMGED TLYSGTVAAA TEGIMFGVPA 130 140 150 160 170 180 IAFSLVDKGW AHLPDAARVA AEIVKHYLAH PLPGQPLLNV NIPNLPYDEL KGWKVTRLGK 190 200 210 220 230 240 RHPSQPVIRQ TDPRGEPIYW IGAAGEALDA SDGTDFHAVA NGFVSITPLQ LDLTHTQMLP 250 ATREWARAGG RAS

References

[1]

"Complete sequence of chromosome 1 of Burkholderia sp. 383." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 383.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000151 Genomic DNA. Translation: ABB08718.1.
RefSeq	YP_369362.1. NC_007510.1.
3D structure databases
ProteinModelPortal	Q39FP8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q39FP8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3750332.
GenomeReviews	Gene locus Bcep18194_A5124 in contig CP000151_GR.
KEGG	bur:Bcep18194_A5124.
NMPDR	fig|269483.3.peg.6199.
PATRIC	19287639. VBIBurSp120713_3224.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0496.
HOGENOM	HBG600532.
OMA	NGFYYVN.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	BSP36773:BCEP18194_A5124-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE2_BURS3

Accession

Primary (citable) accession number: Q39FP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program