Q39FL7 (Q39FL7_BURS3) Unreviewed, UniProtKB/TrEMBL
Last modified
May 1, 2013.
Version 61.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize orderNames and origin
| Protein names | Recommended name: Homoserine dehydrogenase RuleBase RU000579 EC=1.1.1.3 RuleBase RU000579 | ||
| Gene names |
| ||
| Organism | Burkholderia sp. (strain 383) (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) [Complete proteome] [HAMAP] EMBL ABB08749.1 | ||
| Taxonomic identifier | 269483 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex![]() |
Protein attributes
| Sequence length | 442 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H. RuleBase RU000579 |
| Pathway | Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3. RuleBase RU000579 Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5. RuleBase RU000579 |
| Sequence similarities | Belongs to the homoserine dehydrogenase family. RuleBase RU004171 |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis RuleBase RU000579 Methionine biosynthesis RuleBase RU000579 Threonine biosynthesis RuleBase RU000579 |
| Ligand | NADP RuleBase RU000579 PIRSR PIRSR000098-2 |
| Molecular function | Oxidoreductase RuleBase RU000579 EMBL ABB08749.1 |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW methionine biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW threonine biosynthetic processInferred from electronic annotation. Source: UniProtKB-UniPathway |
| Molecular_function | NADP binding Inferred from electronic annotation. Source: InterPro amino acid bindingInferred from electronic annotation. Source: InterPro homoserine dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Regions | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Nucleotide binding | 9 – 16 | 8 | NADP By similarity PIRSR PIRSR000098-2 | ||||||
Sites | |||||||||
| Active site | 208 | 1 | Proton donor By similarity PIRSR PIRSR000098-1 | ||||||
| Binding site | 108 | 1 | NADP By similarity PIRSR PIRSR000098-2 | ||||||
| Binding site | 193 | 1 | Substrate By similarity PIRSR PIRSR000098-2 | ||||||
Sequences
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References
| [1] | "Complete sequence of chromosome 1 of Burkholderia sp. 383." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 383. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000151 Genomic DNA. Translation: ABB08749.1. |
| RefSeq | YP_369393.1. NC_007510.1. |
3D structure databases | |
| ProteinModelPortal | Q39FL7. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 269483.Bcep18194_A5155. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | ABB08749; ABB08749; Bcep18194_A5155. |
| GeneID | 3750364. |
| KEGG | bur:Bcep18194_A5155. |
| PATRIC | 19287701. VBIBurSp120713_3255. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0460. |
| HOGENOM | HOG000076615. |
| KO | K00003. |
| OMA | EWIAGII. |
| ProtClustDB | PRK06349. |
Enzyme and pathway databases | |
| BioCyc | BSP269483:GHLS-5234-MONOMER. |
| UniPathway | UPA00050; UER00063. UPA00051; UER00465. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 1 hit. |
| InterPro | IPR002912. ACT_dom. IPR005106. Asp/hSer_DH_NAD-bd. IPR016204. HDH. IPR001342. HDH_cat. IPR019811. HDH_CS. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Pfam | PF01842. ACT. 1 hit. PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view] |
| PIRSF | PIRSF000098. Homoser_dehydrog. 1 hit. |
| PROSITE | PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | Q39FL7_BURS3 | ||||||||
| Accession | Primary (citable) accession number: Q39FL7 | ||||||||
| Entry history |
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| Entry status | Unreviewed (UniProtKB/TrEMBL) | ||||||||

Clusters with
