ID   Q39FL6_BURL3            Unreviewed;       412 AA.
AC   Q39FL6;
DT   22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2005, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE            EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN   Name=alaA {ECO:0000313|EMBL:KAF1034604.1};
GN   OrderedLocusNames=Bcep18194_A5156 {ECO:0000313|EMBL:ABB08750.1};
GN   ORFNames=GAK33_05421 {ECO:0000313|EMBL:KAF1034604.1};
OS   Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 /
OS   R18194 / 383).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=482957 {ECO:0000313|EMBL:ABB08750.1, ECO:0000313|Proteomes:UP000002705};
RN   [1] {ECO:0000313|Proteomes:UP000002705}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383
RC   {ECO:0000313|Proteomes:UP000002705};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia sp. 383.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABB08750.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=383 {ECO:0000313|EMBL:ABB08750.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia sp. 383.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KAF1034604.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Cluster_DBSCAN_round4_0 {ECO:0000313|EMBL:KAF1034604.1};
RA   Waterworth S.C., Florez L.V., Rees E.R., Hertweck C., Kaltenpoth M.,
RA   Kwan J.C.;
RT   "Horizontal gene transfer to a defensive symbiont with a reduced genome
RT   amongst a multipartite beetle microbiome.";
RL   MBio 11:e02430-19(2020).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|ARBA:ARBA00007441}.
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DR   EMBL; CP000151; ABB08750.1; -; Genomic_DNA.
DR   EMBL; WNDV01000021; KAF1034604.1; -; Genomic_DNA.
DR   RefSeq; WP_011352300.1; NZ_WNDV01000021.1.
DR   AlphaFoldDB; Q39FL6; -.
DR   GeneID; 45095032; -.
DR   KEGG; bur:Bcep18194_A5156; -.
DR   PATRIC; fig|482957.22.peg.2094; -.
DR   HOGENOM; CLU_017584_4_2_4; -.
DR   Proteomes; UP000002705; Chromosome 1.
DR   Proteomes; UP000467522; Unassembled WGS sequence.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   CDD; cd00609; AAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR43488; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   PANTHER; PTHR43488:SF2; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|EMBL:ABB08750.1};
KW   Pyruvate {ECO:0000313|EMBL:KAF1034604.1};
KW   Transferase {ECO:0000313|EMBL:ABB08750.1}.
FT   DOMAIN          35..391
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   412 AA;  45732 MW;  B6DABCEDE33FDE86 CRC64;
     MKPIQKSNKL LNVCYDIRGP VLEHAKRLEE EGHRIIKLNI GNLAPFGFDA PDEIIQDMIR
     NLPTSSGYSD SKGVFSARKA VMHYTQEKGV VGVGLDDIYI GNGASELIVM ATQALLNDGD
     EVLLPAPDYP LWTAAVSLSG GTPVHYICDE QNAWMPDPDD IRRKITPNTK AIVVINPNNP
     TGALYSDELL LELLAIAREH GLIVFADEVY DKIVYDGLEH TALGSLSEDV ITVTFNSLSK
     SYRSCGYRAG WMAVSGLGGD NRRRAKDYLE GLGILSSMRL CANVPGQFAI QTALGGYQSI
     NELIVPSGRL YKQRELAYDM LTSIPGVTCV KPQAALYMFP RLDPKLYPIQ NDQQFILDLL
     LEERVLLVQG TGFNWTTPDH FRVVFLPNLD DLTDSINRIA RFLDGYRKRH SA
//