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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei350Proton donorUniRule annotation1
Active sitei381UniRule annotation1
Active sitei503UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Bcep18194_A5218
OrganismiBurkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002309141 – 540Glucose-6-phosphate isomeraseAdd BLAST540

Structurei

3D structure databases

ProteinModelPortaliQ39FF4.
SMRiQ39FF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261370.
KOiK01810.
OrthoDBiPOG091H04C3.

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39FF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNSLPAWT ALQSHFEQIR HARLRDWFAP ENDHTPTRAE RFTIPGGGIA
60 70 80 90 100
ADFSKNRIND DTLRLLVQLA RDAGVEARRD AMFAGEIVNP TEGRAALHTA
110 120 130 140 150
LRATDPQAPF HAQISAERAK MATFARAVRS GTWTGYTGKR IRHVINIGIG
160 170 180 190 200
GSDLGPKMVV HALHHVATPE ITTHFVSNVD GADLARVLEQ VDPEETLAII
210 220 230 240 250
VSKTFTTLET MTNARSLRDW FVARGCPEDA LAKHFVGVSA NPAEVVKFGI
260 270 280 290 300
AADNVFEMWD WVGGRYSLWS AVGLSIMIAI GPEQFDELLA GANDMDRHFR
310 320 330 340 350
EAPLERNLPV LLGLIGIWYR NFFGSQSYLV APYSEALHYL PSYLQQLEME
360 370 380 390 400
SNGKSARLDG TFVDYPTSAV TWGEPGTNGQ HAFFQMLHQG PTIVPIDFIA
410 420 430 440 450
VLTPEHPLAS HHPKLLANCF AQSEALMLGR TLDEARKVAG PGKEALAPHL
460 470 480 490 500
TFPGNRPTTT LLVDALTPRT LGALIALYEH KVLVQATVWD INPFDQWGVE
510 520 530 540
LGKILGKVVE ADLSAESIDP AKHDSSTTAL IERARAALKR
Length:540
Mass (Da):59,313
Last modified:April 4, 2006 - v2
Checksum:i1F39546BC4690DCA
GO

Sequence cautioni

The sequence ABB08812 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB08812.1. Different initiation.
RefSeqiWP_041492870.1. NC_007510.1.

Genome annotation databases

EnsemblBacteriaiABB08812; ABB08812; Bcep18194_A5218.
KEGGibur:Bcep18194_A5218.
PATRICifig|482957.22.peg.2157.

Similar proteinsi

Entry informationi

Entry nameiG6PI_BURL3
AccessioniPrimary (citable) accession number: Q39FF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: August 30, 2017
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families